Subject    :    [2017 Jun;41(3)] Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes
Writer KDA
Date 2017-07-06 11:10:22 Hit 6,566
Diabetes Metab J. 2017 Jun;41(3):195-204. English.
Published online Jun 21, 2017.  https://doi.org/10.4093/dmj.2017.41.3.195 
Copyright © 2017 Korean Diabetes Association
   
Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes
Mervat M. El-Eshmawy,1 Enas M. Elkhamisy,1 Eman Elsayed,2 and Shaheer Kamal3
1Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.
2Department of Clinical Pathology, Mansoura University Faculty of Medicine, Mansoura, Egypt.
3Department of Cardiology, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.

Corresponding author: Mervat M. El-Eshmawy. Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Elgomhoria St, Mansoura 35516, Egypt. Email: mervat2040@yahoo.com 
 
Received September 03, 2016; Accepted January 20, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

Low circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes.

Methods

This cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed.

Results

Prolactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women.

Conclusion

In prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.

   
Keywords:
Cardiac remodeling; Gender; Prediabetes; Prolactin
 

Articles - Reviews in DMJ
No. Subject Date Hit ↓
197 [2017 Jun;41(3)] Satisfaction Survey on Information Technology-Based... 2017-07-06 6,703
196 [2017 Jun;41(3)] The Effect of 12 Weeks Aerobic, Resistance, and Com... 2017-07-06 6,679
195 [2017 Jun;41(3)] Impact of Gender on the Association between Low Ser... 2017-07-06 6,566
194 [2017 Jun;41(3)] Physician-Directed Diabetes Education without a Med... 2017-07-06 6,233
193 [2017 Jun;41(3)] Knowledge, Attitude, and Practice of Iranian Intern... 2017-07-06 6,359
192 [2017 Jun;41(3)] Comparison of Antidiabetic Regimens in Patients wit... 2017-07-06 6,445
191 [2017 Jun;41(3)] Diabetes Prevention in Australia: 10 Years Results ... 2017-07-06 6,340
190 [2017 Jun;41(3)] Comprehensive Approach for Managing the Older Perso... 2017-07-06 6,016
189 [2017 Apr;41(2)] A Cutoff for Age at Menarche Predicting Metabolic S... 2017-07-06 5,964
188 [2017 Apr;41(2)] Addition of Ipragliflozin to Metformin Treatment in... 2017-07-06 6,308

목록

Gets the previous 5 pages.   Go to previous page.  [1]   2   3   4   5     Go to next page. Gets the next  5 pages.