Subject    :    [2016 Dec;40(6)] Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea
Writer KDA
Date 2017-01-02 14:25:05 Hit 3,971
Diabetes Metab J. 2016 Dec;40(6):482-493. English.
Published online Oct 05, 2016.  https://doi.org/10.4093/dmj.2016.40.6.482 
Copyright © 2016 Korean Diabetes Association
   
Clinical Course and Risk Factors of Diabetic Retinopathy in Patients with Type 2 Diabetes Mellitus in Korea
Jae-Seung Yun,1 Tae-Seok Lim,1 Seon-Ah Cha,1 Yu-Bae Ahn,1 Ki-Ho Song,2 Jin A Choi,3 Jinwoo Kwon,3Donghyun Jee,3 Yang Kyung Cho,3 Yong-Moon Park,4 and Seung-Hyun Ko1
1Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
2Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
3Department of Ophthalmology, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Suwon, Korea.
4Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, U.S. Department of Health and Human Services, Research Triangle Park, NC, USA.

Corresponding author: Seung-Hyun Ko. Division of Endocrinology and Metabolism, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, 93 Jungbu-daero, Paldal-gu, Suwon 16247, Korea. Email: kosh@catholic.ac.kr 
 
Received January 25, 2016; Accepted April 06, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

We investigated clinical course and risk factors for diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).

Methods

A total of 759 patients with T2DM without DR were included from January 2001 to December 2004. Retinopathy evaluation was performed at least annually by ophthalmologists. The severity of the DR was classified into five categories according to the International Clinical Diabetic Retinopathy Severity Scales.

Results

Of the 759 patients, 523 patients (68.9%) completed the follow-up evaluation. During the follow-up period, 235 patients (44.9%) developed DR, and 32 patients (13.6%) progressed to severe nonproliferative DR (NPDR) or proliferative DR (PDR). The mean duration of diabetes at the first diagnosis of mild NPDR, moderate NPDR, and severe NPDR or PDR were 14.8, 16.7, and 17.3 years, respectively. After adjusting multiple confounding factors, the significant risk factors for the incidence of DR risk in patients with T2DM were old age, longer duration of diabetes, higher mean glycosylated hemoglobin (HbA1c), and albuminuria. Even in the patients who had been diagnosed with diabetes for longer than 10 years at baseline, a decrease in HbA1c led to a significant reduction in the risk of developing DR (hazard ratio, 0.73 per 1% HbA1c decrement; 95% confidence interval, 0.58 to 0.91; P=0.005).

Conclusion

This prospective cohort study demonstrates that glycemic control, diabetes duration, age, and albuminuria are important risk factors for the development of DR. More aggressive retinal screening for T2DM patients diagnosed with DR should be required in order to not miss rapid progression of DR.

   
Keywords:
Diabetes mellitus, type 2; Diabetic retinopathy; Risk factors
 

Articles - Reviews in DMJ
No. Subject Date Hit ↓
Notice : [2017 Jun;41(3)] Satisfaction Survey on Information Technology-Based Glucose Monitoring System Targeting Diabetes Mellitus in Private Local Clinics in Korea [2017 Jun;41(3)] Satisfaction Survey on Information Technology-Based... 2017-07-06 2,382
Notice : [2017 Jun;41(3)] The Effect of 12 Weeks Aerobic, Resistance, and Combined Exercises on Omentin-1 Levels and Insulin Resistance among Type 2 Diabetic Middle-Aged Women [2017 Jun;41(3)] The Effect of 12 Weeks Aerobic, Resistance, and Com... 2017-07-06 2,409
Notice : [2017 Jun;41(3)] Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes [2017 Jun;41(3)] Impact of Gender on the Association between Low Ser... 2017-07-06 2,252
Notice : [2017 Jun;41(3)] Physician-Directed Diabetes Education without a Medication Change and Associated Patient Outcomes [2017 Jun;41(3)] Physician-Directed Diabetes Education without a Med... 2017-07-06 2,128
Notice : [2017 Jun;41(3)] Knowledge, Attitude, and Practice of Iranian Internists Regarding Diabetes: A Cross Sectional Study [2017 Jun;41(3)] Knowledge, Attitude, and Practice of Iranian Intern... 2017-07-06 2,174
Notice : [2017 Jun;41(3)] Comparison of Antidiabetic Regimens in Patients with Type 2 Diabetes Uncontrolled by Combination Therapy of Sulfonylurea and Metformin: Results of the MOHAS Disease Registry in Korea [2017 Jun;41(3)] Comparison of Antidiabetic Regimens in Patients wit... 2017-07-06 2,244
Notice : [2017 Jun;41(3)] Diabetes Prevention in Australia: 10 Years Results and Experience [2017 Jun;41(3)] Diabetes Prevention in Australia: 10 Years Results ... 2017-07-06 2,172
Notice : [2017 Jun;41(3)] Comprehensive Approach for Managing the Older Person with Diabetes Mellitus [2017 Jun;41(3)] Comprehensive Approach for Managing the Older Perso... 2017-07-06 2,054
Notice : [2017 Apr;41(2)] A Cutoff for Age at Menarche Predicting Metabolic Syndrome in Egyptian Overweight/Obese Premenopausal Women [2017 Apr;41(2)] A Cutoff for Age at Menarche Predicting Metabolic S... 2017-07-06 2,054
Notice : [2017 Apr;41(2)] Addition of Ipragliflozin to Metformin Treatment in Korean Patients with Type 2 Diabetes Mellitus: Subgroup Analysis of a Phase 3 Trial [2017 Apr;41(2)] Addition of Ipragliflozin to Metformin Treatment in... 2017-07-06 2,199
Notice : [2017 Apr;41(2)] Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with Overt Nephropathy [2017 Apr;41(2)] Lipid Abnormalities in Type 2 Diabetes Mellitus Pat... 2017-07-06 2,137
Notice : [2017 Apr;41(2)] Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density? [2017 Apr;41(2)] Regulating Hypothalamus Gene Expression in Food Int... 2017-07-06 2,167
Notice : [2017 Apr;41(2)] Association between Blood Mercury Level and Visceral Adiposity in Adults [2017 Apr;41(2)] Association between Blood Mercury Level and Viscera... 2017-07-06 2,166
Notice : [2017 Apr;41(2)] Diabetes Camp as Continuing Education for Diabetes Self-Management in Middle-Aged and Elderly People with Type 2 Diabetes Mellitus [2017 Apr;41(2)] Diabetes Camp as Continuing Education for Diabetes ... 2017-07-06 2,254
Notice : [2017 Apr;41(2)] Role of NO/VASP Signaling Pathway against Obesity-Related Inflammation and Insulin Resistance [2017 Apr;41(2)] Role of NO/VASP Signaling Pathway against Obesity-R... 2017-07-06 2,180
Notice : [2017 Apr;41(2)] A Clinical Practice Guideline to Guide a System Approach to Diabetes Care in Hong Kong [2017 Apr;41(2)] A Clinical Practice Guideline to Guide a System App... 2017-07-06 2,144
181 [2017 Feb;41(1)] Exenatide versus Insulin Lispro Added to Basal Insu... 2017-03-23 3,726
180 [2017 Feb;41(1)] Serum Calcium and the Risk of Incident Metabolic Sy... 2017-03-23 3,753
179 [2017 Feb;41(1)] Relationship between Regional Body Fat Distribution... 2017-03-23 3,932
178 [2017 Feb;41(1)] Application of the 2013 American College of Cardiol... 2017-03-23 3,924
177 [2017 Feb;41(1)] Practical Focus on American Diabetes Association/Eu... 2017-03-23 3,837
176 [2017 Feb;41(1)] Efficacy of Moderate Intensity Statins in the Treat... 2017-03-23 3,948
175 [2017 Feb;41(1)] Nuclear Receptors Resolve Endoplasmic Reticulum Str... 2017-03-23 3,826
174 [2017 Feb;41(1)] My Sweetheart Is Broken: Role of Glucose in Diabeti... 2017-03-23 4,000
173 [2016 Dec;40(6)] Investigating Susceptibility to Diabetes Using Feat... 2017-01-02 4,039
172 [2016 Dec;40(6)] Clinical Course and Risk Factors of Diabetic Retino... 2017-01-02 3,971

목록

Gets the previous 5 pages.   Go to previous page.  [1]   2   3   4   5     Go to next page. Gets the next  5 pages.