Subject    :    [2017 Apr;41(2)] Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density?
Writer KDA
Date 2017-07-06 11:01:07 Hit 2,220
Diabetes Metab J. 2017 Apr;41(2):121-127. English.
Published online Dec 16, 2016.  https://doi.org/10.4093/dmj.2017.41.2.121 
Copyright © 2017 Korean Diabetes Association
   
Regulating Hypothalamus Gene Expression in Food Intake: Dietary Composition or Calorie Density?
Mi Jang, So-Young Park, Yong-Woon Kim, Seung-Pil Jung and Jong-Yeon Kim
Obesity-Diabetes Advanced Research Center, Yeungnam University College of Medicine, Daegu, Korea.

Corresponding author: Jong-Yeon Kim. Obesity-Diabetes Advanced Research Center, Yeungnam University College of Medicine, 170 Hyeonchung-ro, Nam-gu, Daegu 42415, Korea. Email: jykim@ynu.ac.kr
 
Received July 08, 2016; Accepted September 13, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Background

The proportion of saturated fatty acids/unsaturated fatty acids in the diet seems to act as a physiological regulation on obesity, cardiovascular diseases, and diabetes. Differently composed fatty acid diets may induce satiety of the hypothalamus in different ways. However, the direct effect of the different fatty acid diets on satiety in the hypothalamus is not clear.

Methods

Three experiments in mice were conducted to determine whether: different compositions of fatty acids affects gene mRNA expression of the hypothalamus over time; different types of fatty acids administered into the stomach directly affect gene mRNA expression of the hypothalamus; and fat composition changes in the diet affects gene mRNA expression of the hypothalamus.

Results

The type of fat in cases of purified fatty acid administration directly into the stomach may cause changes of gene expressions in the hypothalamus. Gene expression by dietary fat may be regulated by calorie amount ingested rather than weight amount or type of fat.

Conclusion

Therefore, the calorie density factor of the diet in regulating hypothalamic gene in food intake may be detrimental, although the possibility of type of fat cannot be ruled out.

   
Keywords:
Dietary fats; Eating; Gene expression; Hypothalamus
 

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