Subject    :    [2017 Apr;41(2)] Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with Overt Nephropathy
Writer KDA
Date 2017-07-06 11:01:54 Hit 7,044

 
Diabetes Metab J. 2017 Apr;41(2):128-134. English.
Published online Jan 11, 2017.  https://doi.org/10.4093/dmj.2017.41.2.128 
Copyright © 2017 Korean Diabetes Association
   
Lipid Abnormalities in Type 2 Diabetes Mellitus Patients with Overt Nephropathy
Sabitha Palazhy, and Vijay Viswanathan
M.V. Hospital for Diabetes & Prof. M. Viswanathan Diabetes Research Centre, Chennai, India.

Corresponding author: Sabitha Palazhy. M.V. Hospital for Diabetes & Prof. M. Viswanathan Diabetes Research Centre, No. 4, West Madha Church St, Royapuram, Chennai 600013, India. Email: sabitha.palazhy@gmail.com 
 
Received April 06, 2016; Accepted November 07, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

Diabetic nephropathy is a major complication of diabetes and an established risk factor for cardiovascular events. Lipid abnormalities occur in patients with diabetic nephropathy, which further increase their risk for cardiovascular events. We compared the degree of dyslipidemia among type 2 diabetes mellitus (T2DM) subjects with and without nephropathy and analyzed the factors associated with nephropathy among them.

Methods

In this retrospective study, T2DM patients with overt nephropathy were enrolled in the study group (n=89) and without nephropathy were enrolled in the control group (n=92). Both groups were matched for age and duration of diabetes. Data on total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), urea and creatinine were collected from the case sheets. TG/HDL-C ratio, a surrogate marker for small, dense, LDL particles (sdLDL) and estimated glomerular filtration rate (eGFR) were calculated using equations. Multivariate analysis was done to determine the factors associated with eGFR.

Results

Dyslipidemia was present among 56.52% of control subjects and 75.28% of nephropathy subjects (P=0.012). The percentage of subjects with atherogenic dyslipidemia (high TG+low HDL-C+sdLDL) was 14.13 among controls and 14.61 among nephropathy subjects. Though serum creatinine was not significantly different, mean eGFR value was significantly lower among nephropathy patients (P=0.002). Upon multivariate analysis, it was found that TC (P=0.007) and HDL-C (P=0.06) were associated with eGFR among our study subjects.

Conclusion

Our results show that dyslipidemia was highly prevalent among subjects with nephropathy. Regular screening for dyslipidemia may be beneficial in controlling the risk for adverse events among diabetic nephropathy patients.

   
Keywords:
Cardiovascular risk; Diabetic nephropathy; Dyslipidemia; Small, dense low density lipoprotein
 

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