Subject    :    [2017 Apr;41(2)] A Cutoff for Age at Menarche Predicting Metabolic Syndrome in Egyptian Overweight/Obese Premenopausal Women
Writer KDA
Date 2017-07-06 11:03:00 Hit 5,920
Diabetes Metab J. 2017 Apr;41(2):146-149. English.
Published online Nov 30, 2016.  https://doi.org/10.4093/dmj.2017.41.2.146 
Copyright © 2017 Korean Diabetes Association
   
A Cutoff for Age at Menarche Predicting Metabolic Syndrome in Egyptian Overweight/Obese Premenopausal Women
Ibrahim Elsehely,1 Hala Abdel Hafez,1 Mohammed Ghonem,1 Ali Fathi,2 and Rasha Elzehery3
1Department of Internal Medicine, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
2Department of Internal Medicine, Demira Hospital, Ministry of Health, Dakhlia, Egypt.
3Department of Clinical Pathology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Corresponding author: Ibrahim Elsehely. Department of Internal Medicine, Faculty of Medicine, Mansoura University, Gomheria St, Mansoura, Egypt. Email: dr_hima_dm@yahoo.com 
 
Received June 17, 2016; Accepted August 26, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Previous studies showed that early age at menarche is associated with increased risk of metabolic syndrome. However, the definition of early menarche at these studies was based on background data in the communities at which these studies was carried on. The aim of this work is to determine a cutoff for age at menarche discriminating presence or absence of metabolic syndrome in overweight/obese premenopausal women. This study included 204 overweight/obese women. Metabolic syndrome was defined according to NCEP-ATP III (National Cholesterol Education Program Adult Treatment Panel III) criteria. Of a total 204 participants, 82 (40.2%) had metabolic syndrome. By using receiver operating characteristic analysis, age at menarche ≤12.25 year discriminated individuals with from those without metabolic syndrome. The area under the curve was 0.76 (95% confidence interval, 0.70 to 0.83). Sensitivity, specificity, negative predictive value, and positive predictive value were 82%, 70%, 85%, and 64%, respectively. Age at menarche ≤12.25 years predicts the presence of metabolic syndrome in overweight/obese women.

   
Keywords:
Menarche; Metabolic syndrome; Overweight
 

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