Subject    :    [2017 Jun;41(3)] Comparison of Antidiabetic Regimens in Patients with Type 2 Diabetes Uncontrolled by Combination Therapy of Sulfonylurea and Metformin: Results of the MOHAS Disease Registry in Korea
Writer KDA
Date 2017-07-06 11:08:31 Hit 7,298
Diabetes Metab J. 2017 Jun;41(3):170-178. English.
Published online May 11, 2017.  https://doi.org/10.4093/dmj.2017.41.3.170 
Copyright © 2017 Korean Diabetes Association
   
Comparison of Antidiabetic Regimens in Patients with Type 2 Diabetes Uncontrolled by Combination Therapy of Sulfonylurea and Metformin: Results of the MOHAS Disease Registry in Korea
Sung Hee Choi,1,2,* Tae Jung Oh,1,2,* and Hak Chul Jang1,2
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
2Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Corresponding author: Hak Chul Jang. Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82 Gumi-ro 173beon-gil, Bundang-gu, Seongnam 13620, Korea. Email: janghak@snu.ac.kr

 

*Sung Hee Choi and Tae Jung Oh contributed equally to this study as first authors.
 
Received September 06, 2016; Accepted November 16, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

The aim of this study was to investigate the glucose-lowering efficacy of antidiabetic treatments in patients with type 2 diabetes mellitus (T2DM) uncontrolled by sulfonylurea plus metformin.

Methods

This open-label, multicenter, prospective, observational study was conducted in 144 centers in Korea, from June 2008 to July 2010, and included patients with T2DM who had received sulfonylurea and metformin for at least 3 months and had levels of glycosylated hemoglobin (HbA1c) >7.0% in the last month. Data of clinical and biochemical characteristics were collected at baseline and 6 months after treatment. The treatment option was decided at the physician's discretion. Subjects were classified into the following three groups: intensifying oral hypoglycemic agents (group A), adding basal insulin (group B), or starting intensified insulin therapy (group C).

Results

Of 2,995 patients enrolled, 2,901 patients were evaluated, and 504 (17.4%), 2,316 (79.8%), and 81 patients (2.8%) were classified into groups A, B, and C, respectively. Subjects in group C showed relatively higher baseline levels of HbA1c and longer duration of diabetes. The mean decrease in HbA1c level was higher in the insulin treated groups (−0.9%±1.3%, −1.6%±1.3%, and −2.4%±2.3% in groups A, B, and C, respectively, P=0.042). The proportion of patients who achieved target HbA1c

Conclusion

These findings suggest that insulin-based therapy will be an important option in the improved management of Korean patients with T2DM whose glycemic control is not sufficient with sulfonylurea and metformin.

   
Keywords:
Diabetes mellitus, type 2; Insulin therapy; Oral hypoglycemic agent
 

Articles - Reviews in DMJ
No. Subject Date Hit ↓
Notice : [2017 Oct;41(5)] Generation of Insulin-Expressing Cells in Mouse Small Intestine by Pdx1, MafA, and BETA2/NeuroD [2017 Oct;41(5)] Generation of Insulin-Expressing Cells in Mouse Sma... 2018-12-03 158
Notice : [2017 Oct;41(5)] Features of Long-Standing Korean Type 2 Diabetes Mellitus Patients with Diabetic Retinopathy: A Study Based on Standardized Clinical Data [2017 Oct;41(5)] Features of Long-Standing Korean Type 2 Diabetes Me... 2018-12-03 164
Notice : [2017 Oct;41(5)] Performance of the Achutha Menon Centre Diabetes Risk Score in Identifying Prevalent Diabetes in Tamil Nadu, India [2017 Oct;41(5)] Performance of the Achutha Menon Centre Diabetes Ri... 2018-12-03 148
Notice : [2017 Oct;41(5)] Effects of Lobeglitazone, a Novel Thiazolidinedione, on Bone Mineral Density in Patients with Type 2 Diabetes Mellitus over 52 Weeks [2017 Oct;41(5)] Effects of Lobeglitazone, a Novel Thiazolidinedione... 2018-12-03 173
Notice : [2017 Oct;41(5)] Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus: A Position Statement of the Korean Diabetes Association, 2017 [2017 Oct;41(5)] Insulin Therapy for Adult Patients with Type 2 Diab... 2018-12-03 139
Notice : [2017 Oct;41(5)] Combination Therapy of Oral Hypoglycemic Agents in Patients with Type 2 Diabetes Mellitus [2017 Oct;41(5)] Combination Therapy of Oral Hypoglycemic Agents in ... 2018-12-03 153
Notice : [2017 Oct;41(5)] Monotherapy in Patients with Type 2 Diabetes Mellitus [2017 Oct;41(5)] Monotherapy in Patients with Type 2 Diabetes Mellit... 2018-12-03 163
Notice : [2017 Oct;41(5)] Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017: A Position Statement of the Korean Diabetes Association [2017 Oct;41(5)] Antihyperglycemic Agent Therapy for Adult Patients ... 2018-12-03 157
Notice : [2017 Oct;41(5)] Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism [2017 Oct;41(5)] Skeletal Muscle Thermogenesis and Its Role in Whole... 2018-12-03 143
Notice : [2017 Aug;41(4)] Factors Associated with Improved Glycemic Control by Direct-Acting Antiviral Agent Treatment in Egyptian Type 2 Diabetes Mellitus Patients with Chronic Hepatitis C Genotype 4 [2017 Aug;41(4)] Factors Associated with Improved Glycemic Control b... 2018-12-03 149
Notice : [2017 Aug;41(4)] In Vitro Effect of Fatty Acids Identified in the Plasma of Obese Adolescents on the Function of Pancreatic β-Cells [2017 Aug;41(4)] In Vitro Effect of Fatty Acids Identified in the P... 2018-12-03 160
Notice : [2017 Aug;41(4)] Depression and Mortality in People with Type 2 Diabetes Mellitus, 2003 to 2013: A Nationwide Population-Based Cohort Study [2017 Aug;41(4)] Depression and Mortality in People with Type 2 Diab... 2018-12-03 157
Notice : [2017 Aug;41(4)] Determinants of Long-Term Durable Glycemic Control in New-Onset Type 2 Diabetes Mellitus [2017 Aug;41(4)] Determinants of Long-Term Durable Glycemic Control ... 2018-12-03 155
Notice : [2017 Aug;41(4)] Effects of High-Dose α-Lipoic Acid on Heart Rate Variability of Type 2 Diabetes Mellitus Patients with Cardiac Autonomic Neuropathy in Korea [2017 Aug;41(4)] Effects of High-Dose α-Lipoic Acid on Heart Rate ... 2018-12-03 154
Notice : [2017 Aug;41(4)] Comparison of Glucose Area Under the Curve Measured Using Minimally Invasive Interstitial Fluid Extraction Technology with Continuous Glucose Monitoring System in Diabetic Patients [2017 Aug;41(4)] Comparison of Glucose Area Under the Curve Measured... 2018-12-03 151
Notice : [2017 Aug;41(4)] The Effectiveness of Green Tea or Green Tea Extract on Insulin Resistance and Glycemic Control in Type 2 Diabetes Mellitus: A Meta-Analysis [2017 Aug;41(4)] The Effectiveness of Green Tea or Green Tea Extract... 2018-12-03 146
Notice : [2017 Aug;41(4)] Unusual Suspects in the Development of Obesity-Induced Inflammation and Insulin Resistance: NK cells, iNKT cells, and ILCs [2017 Aug;41(4)] Unusual Suspects in the Development of Obesity-Indu... 2018-12-03 162
197 [2017 Jun;41(3)] Satisfaction Survey on Information Technology-Based... 2017-07-06 7,594
196 [2017 Jun;41(3)] The Effect of 12 Weeks Aerobic, Resistance, and Com... 2017-07-06 7,528
195 [2017 Jun;41(3)] Impact of Gender on the Association between Low Ser... 2017-07-06 7,483
194 [2017 Jun;41(3)] Physician-Directed Diabetes Education without a Med... 2017-07-06 7,150
193 [2017 Jun;41(3)] Knowledge, Attitude, and Practice of Iranian Intern... 2017-07-06 7,107
192 [2017 Jun;41(3)] Comparison of Antidiabetic Regimens in Patients wit... 2017-07-06 7,298
191 [2017 Jun;41(3)] Diabetes Prevention in Australia: 10 Years Results ... 2017-07-06 7,105
190 [2017 Jun;41(3)] Comprehensive Approach for Managing the Older Perso... 2017-07-06 6,805
189 [2017 Apr;41(2)] A Cutoff for Age at Menarche Predicting Metabolic S... 2017-07-06 6,782
188 [2017 Apr;41(2)] Addition of Ipragliflozin to Metformin Treatment in... 2017-07-06 7,153

목록

Gets the previous 5 pages.   Go to previous page.  [1]   2   3   4   5     Go to next page. Gets the next  5 pages.