Subject    :    [2017 Jun;41(3)] Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes
Writer KDA
Date 2017-07-06 11:10:22 Hit 8,430
Diabetes Metab J. 2017 Jun;41(3):195-204. English.
Published online Jun 21, 2017.  https://doi.org/10.4093/dmj.2017.41.3.195 
Copyright © 2017 Korean Diabetes Association
   
Impact of Gender on the Association between Low Serum Prolactin and Left Ventricular Mass in Subjects with Prediabetes
Mervat M. El-Eshmawy,1 Enas M. Elkhamisy,1 Eman Elsayed,2 and Shaheer Kamal3
1Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.
2Department of Clinical Pathology, Mansoura University Faculty of Medicine, Mansoura, Egypt.
3Department of Cardiology, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Mansoura, Egypt.

Corresponding author: Mervat M. El-Eshmawy. Department of Internal Medicine, Mansoura Specialized Medical Hospital, Mansoura University Faculty of Medicine, Elgomhoria St, Mansoura 35516, Egypt. Email: mervat2040@yahoo.com 
 
Received September 03, 2016; Accepted January 20, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

Low circulating prolactin hormone was associated with increased risk for type 2 diabetes mellitus. An inverse association of serum prolactin with cardiac remodeling was also previously suggested. Thus, the first question arises whether low serum prolactin is associated with adverse cardiac remodeling in subjects with prediabetes and if so what the impact of gender is? Second, could serum prolactin be considered a predictor of cardiac morbidity in those subjects? This study was conducted to assess prolactin level variations in relation to echocardiographic indices of cardiac remodeling among adult men and women with prediabetes.

Methods

This cross sectional study enrolled 80 subjects with prediabetic; 40 men and 40 women. Anthropometric measurements, plasma glucose, lipid profile, homeostasis model assessment of insulin resistance, white blood cells count, prolactin and echocardiography were assessed.

Results

Prolactin was significantly lower in men than in women with prediabetes. Left ventricular mass (LVM) was significantly higher in men than in women with prediabetes. The proportion of left ventricular hypertrophy (LVH) in men with prediabetes was 45% compared with 22.5% in women (P=0.03). We also found inverse independent associations of serum prolactin with LVM and LVH in men, but not in women.

Conclusion

In prediabetes, physiologically low serum prolactin is an independent predictor of increased LVM and LVH in adult men, but not in women. Prolactin may be a potential diagnostic biomarker for cardiac remodeling in adult men with prediabetes.

   
Keywords:
Cardiac remodeling; Gender; Prediabetes; Prolactin
 

Articles - Reviews in DMJ
No. Subject Date Hit ↓
Notice : [2019 Apr;43(2)] Associations between Breastfeeding and Type 2 Diabetes Mellitus and Glycemic Control in Parous Women: A Nationwide, Population-Based Study [2019 Apr;43(2)] Associations between Breastfeeding and Type 2 Diabe... 2019-04-18 6
Notice : [2019 Apr;43(2)] Increased Nociceptive Responses in Streptozotocin-Induced Diabetic Rats and the Related Expression of Spinal NR2B Subunit of N-Methyl-D-Aspartate Receptors [2019 Apr;43(2)] Increased Nociceptive Responses in Streptozotocin-I... 2019-04-18 4
Notice : [2019 Apr;43(2)] The Risk of Myocardial Infarction and Ischemic Stroke According to Waist Circumference in 21,749,261 Korean Adults: A Nationwide Population-Based Study [2019 Apr;43(2)] The Risk of Myocardial Infarction and Ischemic Stro... 2019-04-18 3
Notice : [2019 Apr;43(2)] Myricetin Protects Against High Glucose-Induced β-Cell Apoptosis by Attenuating Endoplasmic Reticulum Stress via Inactivation of Cyclin-Dependent Kinase 5 [2019 Apr;43(2)] Myricetin Protects Against High Glucose-Induced ... 2019-04-18 4
Notice : [2019 Apr;43(2)] Association between Changes in Anthropometric Indices and in Fasting Insulin Levels among Healthy Korean Adolescents: The JS High School Study [2019 Apr;43(2)] Association between Changes in Anthropometric Indic... 2019-04-18 2
Notice : [2019 Apr;43(2)] Discrepancies between Glycosylated Hemoglobin and Fasting Plasma Glucose for Diagnosing Impaired Fasting Glucose and Diabetes Mellitus in Korean Youth and Young Adults [2019 Apr;43(2)] Discrepancies between Glycosylated Hemoglobin and F... 2019-04-18 7
Notice : [2019 Apr;43(2)] Predictors of the Therapeutic Efficacy and Consideration of the Best Combination Therapy of Sodium-Glucose Co-transporter 2 Inhibitors [2019 Apr;43(2)] Predictors of the Therapeutic Efficacy and Consider... 2019-04-18 2
Notice : [2019 Apr;43(2)] Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity [2019 Apr;43(2)] Metabolic Consequences of Obstructive Sleep Apnea E... 2019-04-18 5
Notice : [2019 Apr;43(2)] Nonalcoholic Fatty Liver Disease and Diabetes: Part II: Treatment [2019 Apr;43(2)] Nonalcoholic Fatty Liver Disease and Diabetes: Part... 2019-04-18 5
283 [2019 Feb;43(1)] Higher High Density Lipoprotein 2 (HDL2) to Total H... 2019-03-06 73
282 [2019 Feb;43(1)] Proportion and Characteristics of the Subjects with... 2019-03-06 73
281 [2019 Feb;43(1)] Soluble Dipeptidyl Peptidase-4 Levels Are Associate... 2019-03-06 67
280 [2019 Feb;43(1)] Projection of Diabetes Prevalence in Korean Adults ... 2019-03-06 72
279 [2019 Feb;43(1)] High Proportion of Adult Cases and Prevalence of Me... 2019-03-06 34
278 [2019 Feb;43(1)] Association of Bisphenol A and Its Substitutes, Bis... 2019-03-06 41
277 [2019 Feb;43(1)] Hospital-Based Korean Diabetes Prevention Study: A ... 2019-03-06 54
276 [2019 Feb;43(1)] Nonalcoholic Fatty Liver Disease in Diabetes. Part ... 2019-03-06 65
275 [2019 Feb;43(1)] Update on the Impact, Diagnosis and Management of C... 2019-03-06 51
274 [2018 Dec;42(6)] The Prevalence and Risk Factors for Diabetic Retino... 2019-03-06 46

목록

Gets the previous 5 pages.   Go to previous page.  [1]   2   3   4   5     Go to next page. Gets the next  5 pages.