Subject    :    [2017 Oct;41(5)] Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism
Writer KDA
Date 2018-12-03 18:24:48 Hit 1,124
   
Diabetes Metab J. 2017 Oct;41(5):327-336. English.
Published online Oct 24, 2017.  https://doi.org/10.4093/dmj.2017.41.5.327 
Copyright © 2017 Korean Diabetes Association
   
Skeletal Muscle Thermogenesis and Its Role in Whole Body Energy Metabolism
Muthu Periasamy, Jose Luis Herrera and Felipe C. G. Reis
Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, USA.

Corresponding author: Muthu Periasamy. Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, 6400 Sanger Rd, Orlando, FL 32827, USA. Email: mperiasamy@SBPdiscovery.org 
 
Received August 29, 2017; Accepted September 08, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Obesity and diabetes has become a major epidemic across the globe. Controlling obesity has been a challenge since this would require either increased physical activity or reduced caloric intake; both are difficult to enforce. There has been renewed interest in exploiting pathways such as uncoupling protein 1 (UCP1)-mediated uncoupling in brown adipose tissue (BAT) and white adipose tissue to increase energy expenditure to control weight gain. However, relying on UCP1-based thermogenesis alone may not be sufficient to control obesity in humans. On the other hand, skeletal muscle is the largest organ and a major contributor to basal metabolic rate and increasing energy expenditure in muscle through nonshivering thermogenic mechanisms, which can substantially affect whole body metabolism and weight gain. In this review we will describe the role of Sarcolipin-mediated uncoupling of Sarcoplasmic Reticulum Calcium ATPase (SERCA) as a potential mechanism for increased energy expenditure both during cold and diet-induced thermogenesis.

   
Keywords:
ATP hydrolysisCalcium cyclingDiabetes mellitusObesitySarcolipinSarcoplasmic reticulum calcium-transporting ATPasesSkeletal muscle thermogenesis

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