Subject    :    [2019 Apr;43(2)] Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
Writer KDA
Date 2019-04-18 10:29:07 Hit 1,097
LINK URL https://e-dmj.org/search.php?where=aview&id=10.4093/dmj.2018.0256&code=2004DMJ&vmode=FULL (Click 24)
Diabetes Metab J. 2019 Apr;43(2):144-155. English.
Published online Apr 15, 2019.  https://doi.org/10.4093/dmj.2018.0256 
Copyright © 2019 Korean Diabetes Association
   
Metabolic Consequences of Obstructive Sleep Apnea Especially Pertaining to Diabetes Mellitus and Insulin Sensitivity
Sun Ok Song,1,2,3 Ken He,4 Radhika R. Narla,2,5 Hyun Goo Kang,6 Han Uk Ryu,6 and Edward J. Boyko1,2
1Epidemiologic Research and Information Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
2Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
3Department of Endocrinology and Metabolism, National Health Insurance Service Ilsan Hospital, Goyang, Korea.
4Sleep Medicine Section, Veterans Affairs Pittsburgh Healthcare System, Pittsburgh, PA, USA.
5Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA.
6Department of Neurology, Chonbuk National University Medical School, Jeonju, Korea.

Corresponding author: Han Uk Ryu. Department of Neurology and Research Institute of Clinical Medicine, Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, 20 Geonji-ro, Deokjin-gu, Jeonju 54907, Korea. Email: iory252@naver.com 
 
Received December 09, 2018; Accepted February 19, 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Obstructive sleep apnea (OSA) and diabetes has been known to be closely related to each other and both diseases impact highly on the public health. There are many evidence of reports that OSA is associated with diabetes with a bidirectional correlation. A possible causal mechanism of OSA to diabetes is intermittent hypoxemia and diabetes to OSA is microvascular complication. However, OSA and diabetes have a high prevalence rate in public and shares the common overlap characteristic and risk factors such as age, obesity, and metabolic syndrome that make it difficult to establish the exact pathophysiologic mechanism between them. In addition, studies demonstrating that treatment of OSA may help prevent diabetes or improve glycemic control have not shown convincing result but have become a great field of interest research. This review outlines the bidirectional correlation between OSA and diabetes and explore the pathophysiologic mechanisms by approaching their basic etiologies.

   
Keywords:
Diabetes mellitusInsulin resistanceObesitySleep apnea syndromes
 

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