Subject    :    [2019 Apr;43(2)] Association between Changes in Anthropometric Indices and in Fasting Insulin Levels among Healthy Korean Adolescents: The JS High School Study
Writer KDA
Date 2019-04-18 10:31:34 Hit 827
LINK URL https://e-dmj.org/search.php?where=aview&id=10.4093/dmj.2018.0034&code=2004DMJ&vmode=FULL (Click 14)
Diabetes Metab J. 2019 Apr;43(2):183-191. English.
Published online Jan 22, 2019.  https://doi.org/10.4093/dmj.2018.0034 
Copyright © 2019 Korean Diabetes Association
   
Association between Changes in Anthropometric Indices and in Fasting Insulin Levels among Healthy Korean Adolescents: The JS High School Study
Ji Hye Park,1,2 Seyeon Mun,1 Dong Phil Choi,3 Joo Young Lee,4 and Hyeon Chang Kim2,5
1Department of Public Health, Yonsei University Graduate School, Seoul, Korea.
2Cardiovascular and Metabolic Diseases Etiology Research Center, Yonsei University College of Medicine, Seoul, Korea.
3National Academy of Agricultural Science, Rural Development Administration, Wanju, Korea.
4Department of Medical and Pharmaceutical Affairs, Mapo-gu Health Center, Seoul, Korea.
5Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Korea.

Corresponding author: Hyeon Chang Kim. Department of Preventive Medicine, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea. Email: hckim@yuhs.ac 
 
Received February 19, 2018; Accepted November 08, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

This study investigated the association between changes in anthropometric indices and fasting insulin levels among healthy adolescents and whether the association differed by baseline obesity status.

Methods

This analysis was based on data collected for the JS High School study; 884 healthy adolescents aged 15 to 16 years followed up for 24 to 30 months were included. Changes in anthropometric indices and fasting insulin levels were computed as the difference between baseline and follow-up values. Multivariate linear regression models were used to determine the association between changes in anthropometric indices and fasting insulin levels. Based on body mass index (BMI)-for-age and waist circumference (WC)-for-age percentiles, participants were classified as normal weight (<85th percentile), overweight (85th percentile to <95th percentile), or obese (≥95th percentile).

Results

Changes in BMI, WC, waist-hip ratio, and waist-height ratio were significantly associated with changes in fasting insulin levels in both sexes (P<0.05). In analyses stratified by baseline obesity status, the association between change in BMI and change in fasting insulin was significantly stronger in overweight (males: standardized β=1.136; females: standardized β=1.262) and obese (males: standardized β=1.817; females: standardized β=2.290) participants than in those with normal weight (males: standardized β=0.957; females: standardized β=0.976) at baseline. Results were similar for changes in WC.

Conclusion

Changes in anthropometric indices were positively associated with fasting insulin level increases. Moreover, those who were overweight or obese at baseline had a higher absolute increase in fasting insulin levels per one standard deviation unit increase in anthropometric indices than adolescents with normal weight.

   
Keywords:
AdolescentInsulinObesity

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