Subject    :    [2019 June;43(3)] Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study
Writer KDA
Date 2019-06-28 17:25:23 Hit 841
LINK URL https://e-dmj.org/DOIx.php?id=10.4093/dmj.2018.0060 (Click 41)
Diabetes Metab J. 2019 Jun;43(3):319-341. English.
Published online Apr 19, 2019.  https://doi.org/10.4093/dmj.2018.0060 
Copyright © 2019 Korean Diabetes Association
   
Diabetes Mellitus and Cause-Specific Mortality: A Population-Based Study
Sen Li,1,2,* Jiaxin Wang,1,* Biao Zhang,3 Xinyi Li,4 and Yuan Liu5
1School of Life Sciences, Beijing University of Chinese Medicine, Beijing, China.
2Department of Physiology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong.
3Department of Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
4School of Management, Beijing University of Chinese Medicine, Beijing, China.
5Department of Biostatistics and Bioinformatics, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Corresponding author: Sen Li. School of Life Sciences, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China. Email: senli@connect.hku.hk

 

*Sen Li and Jiaxin Wang contributed equally to this study as first authors.
 
Received April 11, 2018; Accepted November 09, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

To investigate whether diabetes contributes to mortality for major types of diseases.

Methods

Six National Health and Nutrition Examination Survey data cycles (1999 to 2000, 2001 to 2002, 2003 to 2004, 2005 to 2006, 2007 to 2008, and 2009 to 2010) and their linked mortality files were used. A population of 15,513 participants was included according to the availability of diabetes and mortality status.

Results

Participants with diabetes tended to have higher all-cause mortality and mortality due to cardiovascular disease, cancer, chronic lower respiratory diseases, cerebrovascular disease, influenza and pneumonia, and kidney disease. Confounder-adjusted Cox proportional hazard models showed that both diagnosed diabetes category (yes or no) and diabetes status (diabetes, prediabetes, or no diabetes) were associated with all-cause mortality and with mortality due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease. No associations were found for cancer-, accidents-, or Alzheimer's disease-related mortality.

Conclusion

The current study's findings provide epidemiological evidence that diagnosed diabetes at the baseline is associated with increased mortality risk due to cardiovascular disease, chronic lower respiratory diseases, influenza and pneumonia, and kidney disease, but not with cancer or Alzheimer's disease.

   
Keywords:
Diabetes complicationsDiabetes mellitusMortality

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