5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2019 Aug;43(4)] Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus
Writer KDA
Date 2019-10-10 16:48:45 Hit 727
LINK URL https://e-dmj.org/search.php?where=aview&id=10.4093/dmj.2018.0105&code=2004DMJ&vmode=FULL (Click 10)
Diabetes Metab J. 2019 Aug;43(4):495-503. English.
Published online Feb 20, 2019.  https://doi.org/10.4093/dmj.2018.0105
Copyright © 2019 Korean Diabetes Association
   
Factors Related to Blood Intact Incretin Levels in Patients with Type 2 Diabetes Mellitus
Soyeon Yoo,1,2 Eun-Jin Yang,1 and Gwanpyo Koh1,2
1Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Korea.
2Department of Internal Medicine, Jeju National University Hospital, Jeju, Korea.

Corresponding author: Gwanpyo Koh. Department of Internal Medicine, Jeju National University School of Medicine, 15 Aran 13-gil, Jeju 63241, Korea. Email: okdom@jejunu.ac.kr
 
Received June 22, 2018; Accepted November 22, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

We performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes mellitus (T2DM).

Methods

We cross-sectionally analyzed 336 patients with T2DM. Intact glucagon-like peptide 1 (iGLP-1) and intact glucose-dependent insulinotropic polypeptide (iGIP) levels were measured in a fasted state and 30 minutes after ingestion of a standard mixed meal. The differences between 30 and 0 minute iGLP-1 and iGIP levels were indicated as ΔiGLP-1 and ΔiGIP.

Results

In simple correlation analyses, fasting iGLP-1 was positively correlated with glucose, C-peptide, creatinine, and triglyceride levels, and negatively correlated with estimated glomerular filtration rate. ΔiGLP-1 was positively correlated only with ΔC-peptide levels. Fasting iGIP showed positive correlations with glycosylated hemoglobin (HbA1c) and fasting glucose levels, and negative correlations with ΔC-peptide levels. ΔiGIP was negatively correlated with diabetes duration and HbA1c levels, and positively correlated with Δglucose and ΔC-peptide levels. In multivariate analyses adjusting for age, sex, and covariates, fasting iGLP-1 levels were significantly related to fasting glucose levels, ΔiGLP-1 levels were positively related to ΔC-peptide levels, fasting iGIP levels were related to fasting C-peptide levels, and ΔiGIP levels were positively related to ΔC-peptide and Δglucose levels.

Conclusion

Taken together, intact incretin levels are primarily related to C-peptide and glucose levels. This result suggests that glycemia and insulin secretion are the main factors associated with intact incretin levels in T2DM patients.

   
Keywords:
Diabetes mellitus, type 2; Gastric inhibitory polypeptide; Glucagon-like peptide 1; Intact incretin
 

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