Subject    :    [2015 Dec;39(6)] Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?
Writer KDA
Date 2016-01-07 15:51:04 Hit 6,516
Diabetes Metab J. 2015 Dec;39(6):468-477. English. Published online Dec 11, 2015.  http://dx.doi.org/10.4093/dmj.2015.39.6.468 
Copyright © 2015 Korean Diabetes Association
   
Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?
Sung-Hoon Kim
Division of Endocrinology & Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, Seoul, Korea.
Corresponding author: Sung-Hoon Kim. Division of Endocrinology & Metabolism, Department of Medicine, Cheil General Hospital & Women's Healthcare Center, Dankook University College of Medicine, 17 Seoae-ro 1-gil, Jung-gu, Seoul 04619, Korea. Email: hoonie.kim@cgh.co.kr 
 
Received October 02, 2015; Accepted November 25, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been identified to date. A correct genetic diagnosis is important as it often leads to personalized treatment for those with diabetes and enables predictive genetic testing for their asymptomatic relatives. Next-generation sequencing may provide an efficient method for screening mutations in this form of diabetes as well as identifying new MODY genes. In this review, I discuss a current update on MODY in the literatures and cover the studies that have been performed in Korea.

   

Keywords: Diagnosis; Maturity-onset diabetes of the young; Personalized treatment

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