Subject    :    [2015 Feb;39(1)] Hepatokines as a Link between Obesity and Cardiovascular Diseases
Writer KDA
Date 2015-03-05 14:13:13 Hit 5,644
LINK URL http://e-dmj.org/DOIx.php?id=10.4093/dmj.2015.39.1.10 (Click 663)

 
Diabetes Metab J. 2015 Feb;39(1):10-15. English. Published online Feb 16, 2015.  http://dx.doi.org/10.4093/dmj.2015.39.1.10 
Copyright © 2015 Korean Diabetes Association
   
Hepatokines as a Link between Obesity and Cardiovascular Diseases
Hye Jin Yoo and Kyung Mook Choi
Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Corresponding author: Kyung Mook Choi. Division of Endocrinology and Metabolism, Department of Internal Medicine, Korea University Guro Hospital, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul 152-703, Korea. Email: medica7@gmail.com 
 
 

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.

   

 

Keywords: Fetuin-A, Fibroblast growth factor 21, Hepatokines, Non-alcoholic fatty liver disease,Selenoprotein P.

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