Subject    :    [2016 Aug;40(4)] Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring
Writer KDA
Date 2016-08-26 11:41:05 Hit 5,531
LINK URL http://e-dmj.org/DOIx.php?id=10.4093/dmj.2016.40.4.326 (Click 477)
Diabetes Metab J. 2016 Aug;40(4):326-333. English.
Published online Jul 26, 2016.  http://dx.doi.org/10.4093/dmj.2016.40.4.326 
Copyright © 2016 Korean Diabetes Association
   
Evaluation of a Novel Glucose Area Under the Curve (AUC) Monitoring System: Comparison with the AUC by Continuous Glucose Monitoring
Satoshi Ugi,1 Hiroshi Maegawa,1 Katsutaro Morino,1 Yoshihiko Nishio,2 Toshiyuki Sato,3 Seiki Okada,3Yasuo Kikkawa,3 Toshihiro Watanabe,3 Hiromu Nakajima,4 and Atsunori Kashiwagi5
1Department of Medicine, Shiga University of Medical Science, Otsu, Japan.
2Department of Diabetes and Endocrine Medicine, Kagoshima University Graduate School of Medical and Dental Science, Kagoshima, Japan.
3Central Research Laboratories, Sysmex Corporation, Kobe, Japan.
4Department of Clinical Laboratory, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
5Department of Medicine, Kusatsu General Hospital, Kusatsu, Japan.
Corresponding author: Satoshi Ugi. Department of Medicine, Shiga University of Medical Science, Setatsukinowacho, Otsu, Shiga 520-2192, Japan. Email: sugi@belle.shiga-med.ac.jp 
 
Received April 21, 2016; Accepted July 04, 2016.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract
Background

Management of postprandial hyperglycemia is a key aspect in diabetes treatment. We developed a novel system to measure glucose area under the curve (AUC) using minimally invasive interstitial fluid extraction technology (MIET) for simple monitoring of postprandial glucose excursions. In this study, we evaluated the relationship between our system and continuous glucose monitoring (CGM) by comparing glucose AUC obtained using MIET with that obtained using CGM for a long duration.

Methods

Twenty diabetic inpatients wearing a CGM system were enrolled. For MIET measurement, a plastic microneedle array was applied to the skin as pretreatment, and hydrogels were placed on the pretreated area to collect interstitial fluid. Hydrogels were replaced every 2 or 4 hours and AUC was predicted on the basis of glucose and sodium ion levels.

Results

AUC predicted by MIET correlated well with that measured by CGM (r=0.93). Good performances of both consecutive 2- and 4-hour measurements were observed (measurement error: 11.7%±10.2% for 2 hours and 11.1%±7.9% for 4 hours), indicating the possibility of repetitive measurements up to 8 hours. The influence of neither glucose fluctuation nor average glucose level over the measurement accuracy was observed through 8 hours.

Conclusion

Our system showed good relationship with AUC values from CGM up to 8 hours, indicating that single pretreatment can cover a large portion of glucose excursion in a day. These results indicated possibility of our system to contribute to convenient monitoring of glucose excursions for a long duration.

   
Keywords:
Continuous glucose monitoring; Extracellular fluid; Glucose area under the curve; Glucose monitoring;Postprandial glycemic excursion

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