Subject    :    [2018 Apr;42(2)] Primary Cilia as a Signaling Platform for Control of Energy Metabolism
Writer KDA
Date 2019-03-05 17:59:08 Hit 277
Diabetes Metab J. 2018 Apr;42(2):117-127. English.
Published online Apr 19, 2018.  https://doi.org/10.4093/dmj.2018.42.2.117 
Copyright © 2018 Korean Diabetes Association
   
Primary Cilia as a Signaling Platform for Control of Energy Metabolism
Do Kyeong Song,1,2,* Jong Han Choi,1,3,* and Min-Seon Kim1,2,3
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
2Asan Institute for Life Science, University of Ulsan College of Medicine, Seoul, Korea.
3Diabetes Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Corresponding author: Min-Seon Kim. Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. Email: mskim@amc.seoul.kr

 

*Do Kyeong Song and Jong Han Choi contributed equally to this study as first authors.
 
Received January 25, 2018; Accepted February 05, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Obesity has become a common healthcare problem worldwide. Cilia are tiny hair-like organelles on the cell surface that are generated and anchored by the basal body. Non-motile primary cilia have been considered to be evolutionary rudiments until a few decades, but they are now considered as important signaling organelles because many receptors, channels, and signaling molecules are highly expressed in primary cilia. A potential role of primary cilia in metabolic regulation and body weight maintenance has been suspected based on rare genetic disorders termed as ciliopathy, such as Bardet-Biedl syndrome and Alström syndrome, which manifest as obesity. Recent studies have demonstrated involvement of cilia-related cellular signaling pathways in transducing metabolic information in hypothalamic neurons and in determining cellular fate during adipose tissue development. In this review, we summarize the current knowledge about cilia and cilia-associated signaling pathways in the regulation of body metabolism.

   
Keywords:
CiliaHedgehogsMetabolismObesityWnt signaling pathway
 

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