Subject    :    [2018 Jun;42(3)] The Role of Advanced Glycation End Products in Diabetic Vascular Complications
Writer KDA
Date 2019-03-06 09:40:36 Hit 266
Diabetes Metab J. 2018 Jun;42(3):188-195. English.
Published online May 31, 2018.  https://doi.org/10.4093/dmj.2017.0105 
Copyright © 2018 Korean Diabetes Association
   
The Role of Advanced Glycation End Products in Diabetic Vascular Complications
Sang Youl Rhee and Young Seol Kim
Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea.

Corresponding author: Young Seol Kim. Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, 23 Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Korea. Email: ycell00@gmail.com 
 
Received December 27, 2017; Accepted March 29, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

In cases of chronic hyperglycemia, advanced glycation end-products (AGEs) are actively produced and accumulated in the circulating blood and various tissues. AGEs also accelerate the expression of receptors for AGEs, and they play an important role in the development of diabetic vascular complications through various mechanisms. Active interventions for glucose and related risk factors may help improve the clinical course of patients by reducing AGEs. This review summarizes recent updates on AGEs that have a significant impact on diabetic vascular complications.

   
Keywords:
Diabetes complicationsGlycation end products, advancedReceptor for advanced glycation end products

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