Subject    :    Diabetes & Metabolism Journal - Volume 39(6); December 2015
Writer jiyeon
Date 2016-01-19 10:46:24 Hit 2,195
LINK URL http://e-dmj.org/src/dmj_mail_form/dmj-v39n6-eToC.html (Click 297)
 
Diabetes & Metabolism Journal (DMJ) - Open Access
 
Table of Contents Alert
Volume 39(6); December 2015
Featured Articles
Insulin Initiation in Insulin-Naive Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study. Diabetes Metab J 2015;39:481-8.
 
Despite the demonstrated benefits of insulin therapy and existing recommendations in the guidelines for timely initiation of insulin therapy, evidence suggests that insulin utilization and glycemic control remain suboptimal. The MOdaliTy of Insulin treatment eValuation (MOTIV) study was conducted to assess the effect of insulin initiation in Korean patients who were inadequately controlled by oral antidiabetic drugs. In this real-world setting, the initiation of basal insulin provides clinically meaningful improvements in glycemic control and a well-tolerated treatment option in Korean patients with T2DM who are failing to meet targets with oral antidiabetic drugs.
 
Clinical Characteristics and Metabolic Predictors of Rapid Responders to Dipeptidyl Peptidase-4 Inhibitor as an Add-on Therapy to Sulfonylurea and Metformin. Diabetes Metab J 2015;39:489-97.
 
Type 2 diabetes is a progressive disease. When the patient becomes hyperglycemic with submaximal sulfonylurea and metformin, dipeptidyl peptidase-4 (DPP-4) inhibitors could be added on. In this study consisting of 807 patients, we showed that triple combination therapy with DPP-4 inhibitors was effective. Rapid responders with ≥ 25% reduction in HbA1c within 12 weeks (from 10.1% to 6.9%, n = 66) were more likely to be men, had shorter duration of diabetes, and higher glycemic parameter at baseline. Women and the patients with lower body weight, triglyceride, and fasting glucose experienced more hypoglycemia. Proactive dose reduction of sulfonylurea could be considered when a DPP-4 inhibitor is added for rapid responders and hypoglycemia-prone patients.
 
Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes. Diabetes Metab J. 2015;39:498-506.
 
Recent guidelines highlight that glycemic management should be individualized as multiple patients factors. Hypoglycemia is regarded as one of the major barriers to achieving glycemic control targets, and early detection of hypoglycemia is clinically important. In this study, we found that a history of cardiovascular disease was an independent risk factor for the development of severe hypoglycemia after adjusting for other related severe hypoglycemia factors (including cardiovascular autonomic dysfunction) in type 2 diabetes patients without renal dysfunction. Thus, for the patients with cardiovascular disease, modulation of glycemic target and intensive education is needed for the prevention of hypoglycemia.
Reviews
Complications
451
Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy  Kume S, Koya D. Diabetes Metab J. 2015 Dec;39(6):451-460.
Pathophysiology
461
Morphologic Changes in Autonomic Nerves in Diabetic Autonomic Neuropathy  Jin HY, Baek HS, Park TS. Diabetes Metab J. 2015 Dec;39(6):461-467.
Genetics
468
Maturity-Onset Diabetes of the Young: What Do Clinicians Need to Know?  Kim SH. Diabetes Metab J. 2015 Dec;39(6):468-477.
Editorial
Complications
478
Severe Hypoglycemia and Cardiovascular Disease in Type 2 Diabetes  Park HK. Diabetes Metab J. 2015 Dec;39(6):478-480.
Original Articles
Clinical Care/Education
481
Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study  Kim SS, Kim IJ, Kim YK, Yoon KH, Son HY, Park SW, Sung YA, Baek HS. Diabetes Metab J. 2015 Dec;39(6):481-488.
489
Clinical Characteristics and Metabolic Predictors of Rapid Responders to Dipeptidyl Peptidase-4 Inhibitor as an Add-on Therapy to Sulfonylurea and Metformin  Kim YA, Yoo WS, Hong ES, Ku EJ, Park KS, Lim S, Cho YM, Park KS, Jang HC, Choi SH. Diabetes Metab J. 2015 Dec;39(6):489-497.
Complications
498
Cardiovascular Disease Predicts Severe Hypoglycemia in Patients with Type 2 Diabetes  Yun JS, Ko SH, Ko SH, Song KH, Yoo KD, Yoon KH, Park YM, Ahn YB. Diabetes Metab J. 2015 Dec;39(6):498-506.
Obesity and Metabolic Syndrome
507
The Usefulness of the Glycosylated Hemoglobin Level for the Diagnosis of Gestational Diabetes Mellitus in the Korean Population  Ryu AJ, Moon HJ, Na JO, Kim YJ, Kim SJ, Mo SI, Byun JR. Diabetes Metab J. 2015 Dec;39(6):507-511.
Genetics
512
Non-Association between rs7903146 and rs12255372 Polymorphisms in Transcription Factor 7-Like 2 Gene and Type 2 Diabetes Mellitus in Jahrom City, Iran  Pourahmadi M, Erfanian S, Moradzadeh M, Jahromi AS. Diabetes Metab J. 2015 Dec;39(6):512-517.
Others
518
Metformin Promotes Apoptosis but Suppresses Autophagy in Glucose-Deprived H4IIE Hepatocellular Carcinoma Cells  Park DB. Diabetes Metab J. 2015 Dec;39(6):518-527.
Letter
 
528
Letter: Prevalence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh (Diabetes Metab J 2015;39:218-29)  Kawada T. Diabetes Metab J. 2015 Dec;39(6):528-529.
Response
 
530
Response: Prevalence of Depression and Glucose Abnormality in an Urbanizing Rural Population of Bangladesh (Diabetes Metab J 2015;39:218-29)  Natasha K, Hussain A, Azad Khan AK, Bhowmik B. Diabetes Metab J. 2015 Dec;39(6):530.
 
Open Access  DMJ is an open access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. It is indexed in PubMed, PubMed Central, SCOPUS, EMBASE, EBSCO, DOI/CrossRef, Google Scholar, KoreaMed, KoMCI, and KoreaMed Synapse.
Manuscript Submission Manuscripts should be submitted via an online manuscript-submission system of the Korean Diabetes Association (http://e-dmj.org, or http://submit.e-dmj.org). 

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