5 :: KDA, Korean Diabetes Association ::
Subject    :    [2018 Apr;42(2)] Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Writer KDA
Date 2019-03-05 17:58:35 Hit 325
Diabetes Metab J. 2018 Apr;42(2):101-116. English.
Published online Apr 19, 2018.  https://doi.org/10.4093/dmj.2018.42.2.101 
Copyright © 2018 Korean Diabetes Association
   
Effects of Omega-3 Supplementation on Adipocytokines in Prediabetes and Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis of Randomized Controlled Trials
Tarik Becic, and Christian Studenik
Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna, Vienna, Austria.

Corresponding author: Tarik Becic. Department of Pharmacology and Toxicology, Faculty of Life Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, Austria. Email: tarikbecix@gmail.com 
 
Received September 18, 2017; Accepted March 28, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Background

The objective of this systematic review and meta-analysis was to determine the effects of omega-3 supplementation on adipocytokine levels in adult prediabetic and diabetic individuals.

Methods

We searched PubMed, Medline, EMBASE, Scopus, Web of Science, Google Scholar, Cochrane Trial Register, World Health Organization Clinical Trial Registry Platform, and Clinicaltrial.gov Registry from inception to August 1, 2017 for randomized controlled trials. Pooled effects of interventions were assessed as mean difference using random effects model. We conducted a sensitivity, publication bias and subgroup analysis.

Results

Fourteen studies individuals (n=685) were included in the meta-analysis. Omega-3 supplementation increased levels of adiponectin (0.48 µg/mL; 95% confidence interval [CI], 0.27 to 0.68; P<0.00001, n=10 trials), but effects disappeared after sensitivity analysis. Tumor necrosis factor α (TNF-α) levels were reduced (−1.71; 95% CI, −3.38 to −0.14; P=0.03, n=8 trials). Treatment duration shorter than 12 weeks was associated with greater reduction than longer treatment duration. Levels of other adipocytokines were not significantly affected. Publication bias could generally not be excluded.

Conclusion

Eicosapentaenoic acid and docosahexaenoic acid supplementation may increase adiponectin and reduce TNF-α levels in this population group. However, due to overall study heterogeneity and potential publication bias, a cautious interpretation is needed.

   
Keywords:
AdipokinesDiabetes mellitusFatty acids, omega-3
 

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