5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2019 Aug;43(4)] Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study
Writer KDA
Date 2019-10-10 16:57:41 Hit 835
LINK URL https://e-dmj.org/search.php?where=aview&id=10.4093/dmj.2018.0080&code=2004DMJ&vmode=FULL (Click 12)
Diabetes Metab J. 2019 Aug;43(4):521-529. English.
Published online Mar 29, 2019.  https://doi.org/10.4093/dmj.2018.0080
Copyright © 2019 Korean Diabetes Association
   
Increased Serum Angiopoietin-Like 6 Ahead of Metabolic Syndrome in a Prospective Cohort Study
Jun Namkung,1,2 Joon Hyung Sohn,3 Jae Seung Chang,2,3,4 Sang-Wook Park,2,5,6 Jang-Young Kim,2,5,6 Sang-Baek Koh,2,6,7 In Deok Kong,3,4 and Kyu-Sang Park2,3,4
1Department of Biochemistry, Yonsei University Wonju College of Medicine, Wonju, Korea.
2Mitohormesis Research Center, Yonsei University Wonju College of Medicine, Wonju, Korea.
3Institute of Lifestyle Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
4Department of Physiology, Yonsei University Wonju College of Medicine, Wonju, Korea.
5Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
6Institute of Genomic Cohort, Yonsei University Wonju College of Medicine, Wonju, Korea.
7Department of Preventive Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Corresponding author: Jun Namkung. Department of Biochemistry, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Korea. Email: junitive@yonsei.ac.kr Corresponding author: Kyu-Sang Park. Department of Physiology, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Korea. Email: qsang@yonsei.ac.kr
 
Received May 16, 2018; Accepted December 21, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory roles. This study investigated the association between serum ANGPTL6 levels and new-onset metabolic syndrome.

Methods

In total, 221 participants without metabolic syndrome were randomly selected from a rural cohort in Korea. Baseline serum ANGPTL6 levels were measured using an enzyme-linked immunosorbent assay. Anthropometric and biochemical markers were analyzed before and after follow-up examinations.

Results

During an average follow-up period of 2.75 (interquartile range, 0.76) years, 82 participants (37.1%) presented new-onset metabolic syndrome and had higher ANGPTL6 levels before onset than those without metabolic syndrome (48.03±18.84 ng/mL vs. 64.75±43.35 ng/mL, P=0.001). In the multivariable adjusted models, the odds ratio for the development of metabolic syndrome in the highest quartile of ANGPTL6 levels was 3.61 (95% confidence interval, 1.27 to 10.26). The use of ANGPTL6 levels in addition to the conventional components improved the prediction of new-onset metabolic syndrome (area under the receiver operating characteristic curve: 0.775 vs. 0.807, P=0.036).

Conclusion

Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome.

   
Keywords:
ANGPTL6 protein, human; Biomarkers; Metabolic syndrome; Prospective studies; ROC curve
 

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