5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2018 Feb;42(1)] Lack of Evidence of the Role of APOA5 3’UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome
Writer KDA
Date 2019-03-05 17:54:51 Hit 314
Diabetes Metab J. 2018 Feb;42(1):74-81. English.
Published online Feb 23, 2018.  https://doi.org/10.4093/dmj.2018.42.1.74 
Copyright © 2018 Korean Diabetes Association
   
Lack of Evidence of the Role of APOA5 3’UTR Polymorphisms in Iranian Children and Adolescents with Metabolic Syndrome
Samaneh Salehi,1, Modjtaba Emadi-Baygi,1,2, Majdaddin Rezaei,3,4 Roya Kelishadi,5 and Parvaneh Nikpour3,4,5
1Department of Genetics, Faculty of Basic Sciences, Shahrekord University, Shahrekord, Iran.
2Research Institute of Biotechnology, Shahrekord University, Shahrekord, Iran.
3Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
4Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
5Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.

Corresponding author: Parvaneh Nikpour. Department of Genetics and Molecular Biology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. Email: pnikpour@med.mui.ac.ir

 

Samaneh Salehi and Modjtaba Emadi-Baygi contributed equally to this study as first authors.
 
Received April 18, 2017; Accepted August 06, 2017.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Background

Metabolic syndrome (MetS) is a complex and multifactorial disorder characterized by insulin resistance, dyslipidaemia, hyperglycemia, abdominal obesity, and elevated blood pressure. The apolipoprotein A5 (APOA5) gene variants have been reported to correlate with two major components of MetS, including low levels of high density lipoprotein cholesterol (HDL-C) and high levels of triglyceride. In the present study, we explored the associations between five single nucleotide polymorphisms (SNPs) of APOA5 gene and the MetS risk.

Methods

In a case-control design, 120 Iranian children and adolescents with/without MetS were genotyped by polymerase chain reaction-sequencing for these SNPs. Then, we investigated the association of SNPs, individually or in haplotype constructs, with MetS risk.

Results

The rs34089864 variant and H1 haplotype (harboring the two major alleles of rs619054 and rs34089864) were associated with HDL-C levels. However, there was no significant association between different haplotypes/individual SNPs and MetS risk.

Conclusion

These results presented no association of APOA5 3’UTR SNPs with MetS. Further studies, including other polymorphisms, are required to investigate the involvement of APOA5 gene in the genetic susceptibility to MetS in the pediatric age group.

   
Keywords:
Apolipoprotein A-VHaplotypesMetabolic syndromemiR-TS-SNP
 

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