5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2019 Aug;43(4)] Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study
Writer KDA
Date 2019-10-10 16:45:59 Hit 781
LINK URL https://e-dmj.org/search.php?where=aview&id=10.4093/dmj.2018.0171&code=2004DMJ&vmode=FULL (Click 15)
Diabetes Metab J. 2019 Aug;43(4):474-486. English.
Published online Mar 20, 2019.  https://doi.org/10.4093/dmj.2018.0171
Copyright © 2019 Korean Diabetes Association
   
Plasma Fetuin-A Levels and Risk of Type 2 Diabetes Mellitus in A Chinese Population: A Nested Case-Control Study
Yeli Wang,1 Woon-Puay Koh,1,2 Majken K. Jensen,3,4 Jian-Min Yuan,5,6 and An Pan7
1Health Services and Systems Research, Duke-NUS Medical School, Singapore.
2Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore.
3Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
5Division of Cancer Control and Population Sciences, UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA, USA.
6Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA.
7Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Corresponding author: An Pan. Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hubei, Wuhan 430030, China. Email: panan@hust.edu.cn Corresponding author: Woon-Puay Koh. Health Services and Systems Research, Duke-NUS Medical School, 169857, Singapore. Email: woonpuay.koh@duke-nus.edu.sg
 
Received September 01, 2018; Accepted December 01, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Background

Fetuin-A is a hepatokine that involved in the pathogenesis of insulin resistance. Previous epidemiological studies have found a positive association between blood fetuin-A and type 2 diabetes mellitus (T2DM) risk among Caucasians and African Americans. We aimed to investigate the prospective relationship between fetuin-A and T2DM in an Asian population for the first time.

Methods

A nested case-control study was established within a prospective cohort of Chinese living in Singapore. At blood collection (1999 to 2004), all participants were free of diagnosed T2DM and aged 50 to 79 years. At subsequent follow-up (2006 to 2010), 558 people reported to have T2DM and were classified as incident cases, and 558 controls were randomly chosen from the participants who did not develop T2DM to match with cases on age, sex, dialect group, and date of blood collection. Plasma fetuin-A levels were measured retrospectively in cases and controls using samples collected at baseline. Conditional logistic regression models were used to compute the odds ratio (OR) and 95% confidence interval (CI). Restricted cubic spline analysis was used to examine a potential non-linear association between fetuin-A levels and T2DM risk.

Results

Compared with those in the lowest fetuin-A quintile, participants in the highest quintile had a two-fold increased risk of developing T2DM (OR, 2.06; 95% CI, 1.21 to 3.51). A non-linear association was observed (P nonlinearity=0.005), where the association between fetuin-A levels and T2DM risk plateaued at plasma concentrations around 830 µg/mL.

Conclusion

There is a positive association between plasma fetuin-A levels and risk of developing T2DM in this Chinese population.

   
Keywords:
Alpha-2-HS-glycoprotein; Association; Case-control studies; Diabetes mellitus, type 2; Epidemiology

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