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Subject    :    [2015 Oct;39(5)] The Association between Hypertension Comorbidity and Microvascular Complications in Type 2 Diabetes Patients: A Nationwide Cross-Sectional Study in Thailand
Writer KDA
Date 2015-12-08 10:15:33 Hit 6,506

 
Diabetes Metab J. 2015 Oct;39(5):395-404. English. Published online Oct 22, 2015.  http://dx.doi.org/10.4093/dmj.2015.39.5.395 
Copyright © 2015 Korean Diabetes Association
   
The Association between Hypertension Comorbidity and Microvascular Complications in Type 2 Diabetes Patients: A Nationwide Cross-Sectional Study in Thailand
Cameron Hurst,1,2 Bandit Thinkhamrop,1 and Hoang The Tran1,3
1Faculty of Public Health, Khon Kaen University, Khon Kaen, Thailand.
2Clinical Epidemiology Unit, Khon Kaen University Faculty of Medicine, Khon Kaen, Thailand.
3Faculty of Public Health, Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam.
Corresponding author: Cameron Hurst. Clinical Epidemiology Unit, Srinagarind Hospital, Khon Kaen University Faculty of Medicine, 123 Alley 16, Mittraparp Highway, Muang District, Khon Kaen 40002, Thailand.Email: cphurst@gmail.com 
 
Received March 16, 2015; Accepted June 19, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract
Background

Type 2 diabetes mellitus (T2DM) is a global pandemic and its prevalence is rapidly increasing in developing countries, including Thailand. The most common comorbidity of T2DM is hypertension. T2DM with a hypertension comorbidity is likely to exacerbate the development of, or more severe microvascular complications. This study aims to determine the association between the hypertension comorbidity and microvascular complication among T2DM patients in Thailand.

Methods

The present study is a nationwide, multicenter, cross-sectional survey of T2DM outpatients across Thailand. Binary logistic mixed effect regression was used to investigate the effect of hypertension and other risk factors on the presence of microvascular complications. Imputation was used to investigate potential bias introduced by missing values.

Results

Of the 55,797 T2DM patients included in our sample, 55.35% were hypertensive. Prevalence of microvascular complication diagnosis in the last 12 months was higher in T2DM patients with hypertension than those without hypertension (12.12% vs. 9.80%, respectively). Patient with a hypertension comorbidity had 1.32 time the odds of developing microvascular complication (adjusted odds ratio [OR], 1.32; 95% confidence interval [CI], 1.20 to 1.46; Page, 1.07; 95% CI, 1.03 to 1.12; Pduration, 1.12; 95% CI, 1.07 to 1.16; P

Conclusion

Hypertension comorbidity is highly associated with microvascular complication among T2DM patients. Patients with T2DM and physicians should pay attention to blood pressure control.

   

Keywords: Diabetes mellitus, type 2, Hypertension, Microvascular complication, Thailand.

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