5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2019 Aug;43(4)] Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus
Writer KDA
Date 2019-10-10 16:59:17 Hit 882
LINK URL https://e-dmj.org/search.php?where=aview&id=10.4093/dmj.2018.0111&code=2004DMJ&vmode=FULL (Click 11)
Diabetes Metab J. 2019 Aug;43(4):530-538. English.
Published online Feb 20, 2019.  https://doi.org/10.4093/dmj.2018.0111
Copyright © 2019 Korean Diabetes Association
   
Impact of Longitudinal Changes in Metabolic Syndrome Status over 2 Years on 10-Year Incident Diabetes Mellitus
Ji Hye Huh,1,* Sung Gyun Ahn,1,* Young In Kim,1 Taehwa Go,2 Ki-Chul Sung,3 Jae Hyuk Choi,4 Kwang Kon Koh,5 and Jang Young Kim1
1Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
2Center of Biomedical Data Science, Yonsei University Wonju College of Medicine, Wonju, Korea.
3Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
4Division of Cardiology, Department of Internal Medicine, Hallym University Hangang Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
5Division of Cardiology, Department of Internal Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, Incheon, Korea.

Corresponding author: Jang Young Kim. Division of Cardiology, Department of Internal Medicine, Wonju Severance Christian Hospital, Yonsei University Wonju College of Medicine, 20 Ilsan-ro, Wonju 26426, Korea. Email: kimjang713@gmail.com Corresponding author: Kwang Kon Koh. Cardiometabolic Syndrome Unit, Department of Cardiovascular Medicine, Gachon University Gil Medical Center, Gachon University College of Medicine, 21 Namdong-daero 774beon-gil, Namdong-gu, Incheon 21565, Korea. Email: kwangk@gilhospital.com

 

*Ji Hye Huh and Sung Gyun Ahn contributed equally to this study as first authors.
 
Received July 01, 2018; Accepted December 10, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Background

Metabolic syndrome (MetS) is a known predictor of diabetes mellitus (DM), but whether longitudinal changes in MetS status modify the risk for DM remains unclear. We investigated whether changes in MetS status over 2 years modify the 10-year risk of incident DM.

Methods

We analyzed data from 7,317 participants aged 40 to 70 years without DM at baseline, who took part in 2001 to 2011 Korean Genome Epidemiology Study. Subjects were categorized into four groups based on repeated longitudinal assessment of MetS status over 2 years: non-MetS, resolved MetS, incident MetS, and persistent MetS. The hazard ratio (HR) of new-onset DM during 10 years was calculated in each group using Cox models.

Results

During the 10-year follow-up, 1,099 participants (15.0%) developed DM. Compared to the non-MetS group, the fully adjusted HRs for new-onset DM were 1.28 (95% confidence interval [CI], 0.92 to 1.79) in the resolved MetS group, 1.75 (95% CI, 1.30 to 2.37) in the incident MetS group, and 1.98 (95% CI, 1.50 to 2.61) in the persistent MetS group (P for trend

Conclusion

We found that discrete longitudinal changes pattern in MetS status over 2 years associated with 10-year risk of DM. These findings suggest that monitoring change of MetS status and controlling it in individuals may be important for risk prediction of DM.

   
Keywords:
Diabetes mellitus; Life style; Metabolic syndrome
 

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