5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2015 Dec;39(6)] Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
Writer KDA
Date 2016-01-07 15:52:36 Hit 6,322
Diabetes Metab J. 2015 Dec;39(6):481-488. English. Published online Nov 25, 2015.  http://dx.doi.org/10.4093/dmj.2015.39.6.481 
Copyright © 2015 Korean Diabetes Association
   
Insulin Initiation in Insulin-Naïve Korean Type 2 Diabetic Patients Inadequately Controlled on Oral Antidiabetic Drugs in Real-World Practice: The Modality of Insulin Treatment Evaluation Study
Sang Soo Kim,1,2 In Joo Kim,1,2 Yong Ki Kim,3 Kun Ho Yoon,4 Ho Young Son,5 Sung Woo Park,6 Yeon Ah Sung,7 and Hong Sun Baek8
1Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Korea.
2Biomedical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine, Busan. Korea.
3Kim Yong Ki Internal Medicine Clinic, Busan, Korea.
4Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
5Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.
6Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
7Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.
8Department of Internal Medicine, Chonbuk National University Medical School, Jeonju, Korea.
Corresponding author: In Joo Kim. Division of Endocrinology and Metabolism, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan 49241, Korea. Email: injkim@pusan.ac.kr 
 
Received November 21, 2014; Accepted March 27, 2015.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract
Background

The Modality of Insulin Treatment Evaluation (MOTIV) study was performed to provide real-world data concerning insulin initiation in Korean type 2 diabetes mellitus (T2DM) patients with inadequate glycemic control with oral hypoglycemic agents (OHAs).

Methods

This multicenter, non-interventional, prospective, observational study enrolled T2DM patients with inadequate glycemic control (glycosylated hemoglobin [HbA1c] ≥7.0%) who had been on OHAs for ≥3 months and were already decided to introduce basal insulin by their physician prior to the start of the study. All treatment decisions were at the physician's discretion to reflect real-world practice.

Results

A total of 9,196 patients were enrolled, and 8,636 patients were included in the analysis (mean duration of diabetes, 8.9 years; mean HbA1c, 9.2%). Basal insulin plus one OHA was the most frequently (51.0%) used regimen. After 6 months of basal insulin treatment, HbA1c decreased to 7.4% and 44.5% of patients reached HbA1cP

Conclusion

In a real-world setting, the initiation of basal insulin is an effective and well-tolerated treatment option in Korean patients with T2DM who are failing to meet targets with OHA therapy.

   

Keywords: Basal insulin; Diabetes mellitus, type 2; Korea; Pragmatic clinical trials as topic

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