5 :: KDA, Korean Diabetes Association ::
Subject    :    [2018 Jun;42(3)] Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
Writer KDA
Date 2019-03-06 09:44:22 Hit 482
Diabetes Metab J. 2018 Jun;42(3):207-214. English.
Published online May 02, 2018.  https://doi.org/10.4093/dmj.2017.0081 
Copyright © 2018 Korean Diabetes Association
   
Serum Levels of PCSK9 Are Associated with Coronary Angiographic Severity in Patients with Acute Coronary Syndrome
Kwi-Hyun Bae,1,* Sung Woo Kim,2,* Yeon-Kyung Choi,1 Jung Beom Seo,1 Namkyun Kim,1 Chang-Yeon Kim,2 Won Kee Lee,3 Sungwoo Lee,4 Jung Guk Kim,1 In-Kyu Lee,1 Jang Hoon Lee,1 and Keun-Gyu Park1
1Department of Internal Medicine, School of Medicine, Kyungpook National University, Daegu, Korea.
2Department of Internal Medicine, Daegu Catholic University Medical Center, Catholic University of Daegu School of Medicine, Daegu, Korea.
3Biostatistics Center, School of Medicine, Kyungpook National University, Daegu, Korea.
4New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Korea.

Corresponding authors: Keun-Gyu Park. Department of Internal Medicine, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea. Email: kpark@knu.ac.kr Corresponding authors: Jang Hoon Lee. Department of Internal Medicine, School of Medicine, Kyungpook National University, 680 Gukchaebosang-ro, Jung-gu, Daegu 41944, Korea. Email: ljhmh75@knu.ac.kr

 

*Kwi-Hyun Bae and Sung Woo Kim contributed equally to this study as first authors.
 
Received November 21, 2017; Accepted January 05, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a circulating protein that promotes degradation of the low density lipoprotein receptor. PCSK9 has emerged as a target for lipid-lowering therapy, but the predictive value of the serum level of PCSK9 for the severity of coronary disease is largely unknown.

Methods

From December 2009 to July 2012, 121 individuals who underwent coronary angiography (CAG) because of clinically suspected acute coronary syndrome were enrolled in this study. Serum levels of PCSK9 and metabolic parameters were measured. SYNTAX (SYNergy between percutaneous coronary intervention with [paclitaxel-eluting] TAXUS stent and cardiac surgery) and GRACE (Global Registry of Acute Coronary Events) scores were calculated.

Results

Individuals with CAG lesions (n=100) had significantly higher levels of PCSK9 than those without lesions (n=21). The study population was stratified into three groups according to serum levels of PCSK9. The odds radio for occurrence of one or more CAG lesions was significantly higher in the group with the highest level of PCSK9 (odds ratio, 7.468; P=0.011) than in the group with the lowest level of PCSK9. Serum PCSK9 was positively associated with the number of involved coronary arteries. Multivariable linear regression indicated that levels of PCSK9 were positively correlated with GRACE risk scores and SYNTAX scores.

Conclusion

Serum PCSK9 concentrations are higher in patients with coronary artery lesions, and are associated with SYNTAX and GRACE scores, suggesting that PCSK9 is a potential biomarker of the severity of coronary artery disease.

   
Keywords:
Cardiovascular diseasesCoronary angiographyProprotein convertase 9
 

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