5 :: KDA, Korean Diabetes Association ::
Subject    :    [2018 Jun;42(3)] Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats
Writer KDA
Date 2019-03-06 09:47:27 Hit 438
Diabetes Metab J. 2018 Jun;42(3):244-248. English.
Published online Apr 24, 2018.  https://doi.org/10.4093/dmj.2018.0002 
Copyright © 2018 Korean Diabetes Association
   
Synthesis of a New Zinc-Mixed Ligand Complex and Evaluation of Its Antidiabetic Properties in High Fat Diet: Low Dose Streptozotocin Induced Diabetic Rats
Muruganantham Koothappan,1 Roshana Devi Vellai,1 Iyyam Pillai Subramanian,2 and Sorimuthu Pillai Subramanian1
1Department of Biochemistry, University of Madras, Guindy Campus, Chennai, India.
2PG and Research Department of Chemistry, Pachaiyappa's College, Chennai, India.

Corresponding author: Sorimuthu Pillai Subramanian. Department of Biochemistry, Guindy Campus, University of Madras, Chennai 600025, India. Email: subbus2020@yahoo.co.in 
 
Received January 03, 2018; Accepted February 20, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Due to the multifactorial and multisystemic nature of diabetes mellitus, it is often treated with a combination of therapeutic agents having different mode of action. Earlier, we have synthesized several organozinc complexes and evaluated their safety and antidiabetic properties in experimental type 2 diabetes mellitus (T2DM). More recently, we have synthesized a metformin-3-hydroxyflavone complex and studied its antidiabetic efficacy in experimental rats. In the present study, a new zinc-mixed ligand (metformin-3-hydroxyflavone) was synthesized, characterized by spectral studies and its antidiabetic properties was evaluated in HFD fed—low dose streptozotocin induced T2DM in rats. The hypoglycemic efficacy of the complex was evaluated through oral glucose tolerance test, homeostasis model assessment of insulin resistance, quantitative insulin sensitivity check index and by determining the status of important biochemical parameters. Oral administration of the complex at a concentration of 10 mg/kg body weight/rat/day for 30 days significantly improved the glucose homeostasis. The complex possesses significant antidiabetic properties relatively at a less concentration than metformin-3-hydroxyflavone complex in ameliorating hyperglycemia.

   
Keywords:
Diabetes mellitus, type 2Hypoglycemic agentsMetforminRatsZinc
 

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