5 :: KDA, Korean Diabetes Association ::
Subject    :    [2018 Aug;42(4)] Diagnosing Diabetic Neuropathy: Something Old, Something New
Writer KDA
Date 2019-03-06 09:52:16 Hit 453
   
Diabetes Metab J. 2018 Aug;42(4):255-269. English.
Published online Aug 21, 2018.  https://doi.org/10.4093/dmj.2018.0056 
Copyright © 2018 Korean Diabetes Association
   
Diagnosing Diabetic Neuropathy: Something Old, Something New
Ioannis N. Petropoulos, Georgios Ponirakis, Adnan Khan, Hamad Almuhannadi, Hoda Gad and Rayaz A. Malik
Division of Research, Weill Cornell Medicine Qatar, Doha, Qatar.

Corresponding author: Rayaz A. Malik. Division of Research, Weill Cornell Medicine Qatar, Qatar Foundation, Education City, P.O. Box 24144, Doha, Qatar. Email: ram2045@qatar-med.cornell.edu 
 
Received April 03, 2018; Accepted May 28, 2018.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.



Abstract

There are potentially many ways of assessing diabetic peripheral neuropathy (DPN). However, they do not fulfill U.S. Food and Drug Administration (FDA) requirements in relation to their capacity to assess therapeutic benefit in clinical trials of DPN. Over the past several decades symptoms and signs, quantitative sensory and electrodiagnostic testing have been strongly endorsed, but have consistently failed as surrogate end points in clinical trials. Therefore, there is an unmet need for reliable biomarkers to capture the onset and progression and to facilitate drug discovery in DPN. Corneal confocal microscopy (CCM) is a non-invasive ophthalmic imaging modality for in vivoevaluation of sensory C-fibers. An increasing body of evidence from multiple centers worldwide suggests that CCM fulfills the FDA criteria as a surrogate endpoint of DPN.

   
Keywords:
ComplicationsDiabetic neuropathiesDiagnosis
 

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