5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2015 Jun;39(3)] Serum Ceruloplasmin Level as a Predictor for the Progression of Diabetic Nephropathy in Korean Men with Type 2 Diabetes Mellitus
Writer KDA
Date 2015-07-07 18:33:00 Hit 5,403
LINK URL http://www.e-dmj.org/DOIx.php?id=10.4093/dmj.2015.39.3.230 (Click 420)
Diabetes Metab J. 2015 Jun;39(3):230-239. English. Published online Apr 22, 2015.  http://dx.doi.org/10.4093/dmj.2015.39.3.230 
Copyright © 2015 Korean Diabetes Association
   
Serum Ceruloplasmin Level as a Predictor for the Progression of Diabetic Nephropathy in Korean Men with Type 2 Diabetes Mellitus
Min Jung Lee,* Chang Hee Jung,* Yu Mi Kang, Jung Eun Jang, Jaechan Leem, Joong-Yeol Park and Woo Je Lee
Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
Corresponding author: Woo Je Lee. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 138-736, Korea. Email:lwjatlas@amc.seoul.kr

 

*Min Jung Lee and Chang Hee Jung contributed equally to this study as first authors.
 
Received July 18, 2014; Accepted September 12, 2014.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract
Background

Oxidative stress is known to be associated with progression of diabetic kidney disease. Ceruloplasmin acts as a pro-oxidant under conditions of severe oxidative stress. Thus, we conducted a longitudinal observational study to evaluate whether the serum ceruloplasmin level is a predictive biomarker for progression of diabetic nephropathy.

Methods

A total of 643 Korean men with type 2 diabetes mellitus were enrolled. Serum ceruloplasmin was measured using a nephelometric method. Progression of diabetic nephropathy was defined as transition in albuminuria class (i.e., normoalbuminuria to microalbuminuria, microalbuminuria to macroalbuminuria, or normoalbuminuria to macroalbuminuria) and/or a greater than 2-fold increase of serum creatinine at follow-up compared with the baseline value.

Results

During the follow-up period (median, 2.7 years; range, 0.3 to 4.4 years), 49 of 643 patients (7.6%) showed the progression of diabetic nephropathy and three patients (0.5%) developed end-stage renal disease. Baseline ceruloplasmin levels were higher in the progressors than in the nonprogressors (262.6±40.9 mg/L vs. 233.3±37.8 mg/L, P P P=0.003).

Conclusion

Baseline serum ceruloplasmin is an independent predictive factor for the progression of diabetic nephropathy in patients with type 2 diabetes mellitus.

   

 

Keywords: Ceruloplasmin, Diabetic nephropathies, Oxidative stress.

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