5 :: KDA, Korean Diabetes Association ::
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Subject    :    [2019 June;43(3)] Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Writer KDA
Date 2019-06-18 14:30:19 Hit 2,326
Diabetes Metab J. 2019 Jun;43(3):247-256. English.
Published online Mar 27, 2019.  https://doi.org/10.4093/dmj.2018.0221 
Copyright © 2019 Korean Diabetes Association
   
Mitochondrial Dysfunction in Adipocytes as a Primary Cause of Adipose Tissue Inflammation
Chang-Yun Woo,1 Jung Eun Jang,2 Seung Eun Lee,3 Eun Hee Koh,1 and Ki-Up Lee1
1Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Korea.
2Department of Internal Medicine, Inje University Haeundae Paik Hospital, Inje University College of Medicine, Busan, Korea.
3Department of Internal Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Goyang, Korea.

Corresponding author: Ki-Up Lee. Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea. Email: kulee@amc.seoul.kr 
 
Received October 31, 2018; Accepted January 19, 2019.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
Abstract

Adipose tissue inflammation is considered a major contributing factor in the development of obesity-associated insulin resistance and cardiovascular diseases. However, the cause of adipose tissue inflammation is presently unclear. The role of mitochondria in white adipocytes has long been neglected because of their low abundance. However, recent evidence suggests that mitochondria are essential for maintaining metabolic homeostasis in white adipocytes. In a series of recent studies, we found that mitochondrial function in white adipocytes is essential to the synthesis of adiponectin, which is the most abundant adipokine synthesized from adipocytes, with many favorable effects on metabolism, including improvement of insulin sensitivity and reduction of atherosclerotic processes and systemic inflammation. From these results, we propose a new hypothesis that mitochondrial dysfunction in adipocytes is a primary cause of adipose tissue inflammation and compared this hypothesis with a prevailing concept that “adipose tissue hypoxia” may underlie adipose tissue dysfunction in obesity. Recent studies have emphasized the role of the mitochondrial quality control mechanism in maintaining mitochondrial function. Future studies are warranted to test whether an inadequate mitochondrial quality control mechanism is responsible for mitochondrial dysfunction in adipocytes and adipose tissue inflammation.

   
Keywords:
Adipocytes; Adiponectin; Hypoxia; Inflammation; Mitochondria; Mitochondrial quality control; Nitric oxide; Obesity; 11-Beta-hydroxysteroid dehydrogenases

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