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- [2022 Mar;46(2)] Mean and Variability of Lipid Measurements and Risk for Development of Subclinical Left Ventricular Diastolic Dysfunction
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- 2022.07.15
- Hit 356
- https://e-dmj.org/journal/view.php?number=2600 (클릭 220회)
Jiyun Park1
, Mira Kang2,3
, Jiyeon Ahn4, Min Young Kim1, Min Sun Choi1, You-Bin Lee1, Gyuri Kim1, Kyu Yeon Hur1, Jae Hyeon Kim1, Jeong Hoon Yang5,6, Sang-Man Jin1
, Mira Kang2,3, Jiyeon Ahn4, Min Young Kim1, Min Sun Choi1, You-Bin Lee1, Gyuri Kim1, Kyu Yeon Hur1, Jae Hyeon Kim1, Jeong Hoon Yang5,6, Sang-Man Jin1Corresponding authors: Sang-Man Jin https://orcid.org/0000-0001-5929-3627 Division of Endocrinology and Metabolism, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea E-mail: sangman.jin@samsung.com
Mira Kang https://orcid.org/0000-0002-7842-0035 Center for Health Promotion, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul 06351, Korea E-mail: mira90.kang@samsung.com
Received April 29, 2021 Accepted September 8, 2021
Abstract
Background
Subclinical left ventricular diastolic dysfunction (LVDD) is an emerging consequence of increased insulin resistance, and dyslipidemia is one of the few correctable risk factors of LVDD. This study evaluated the role of mean and visit-to-visit variability of lipid measurements in risk of LVDD in a healthy population.
Methods
This was a 3.7-year (interquartile range, 2.1 to 4.9) longitudinal cohort study including 2,817 adults (median age 55 years) with left ventricular ejection fraction >50% who underwent an annual or biannual health screening between January 2008 and July 2016. The mean, standard deviation (SD), coefficient of variation (CV), variability independent of the mean (VIM), and average real variability of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), apolipoprotein B (apoB), non-HDL-C, and triglycerides were obtained from three to six measurements during the 5 years preceding the first echocardiogram.
Results
Among the 2,817 patients, 560 (19.9%) developed LVDD. The mean of no component of lipid measurements was associated with risk of LVDD. CV (hazard ratio [HR], 1.35; 95% confidence interval [CI], 1.10 to 1.67), SD (HR, 1.27; 95% CI, 1.03 to 1.57), and VIM (HR, 1.26; 95% CI, 1.03 to 1.55) of LDL-C and all the variability parameters of apoB were significantly associated with development of LVDD. The association between CV-LDL and risk of LVDD did not have significant interaction with sex, increasing/decreasing trend at baseline, or use of stain and/or lipid-modifying agents.
Conclusion
The variability of LDL-C and apoB, rather than their mean, was associated with risk for LVDD.
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