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Diabetes & Metabolism Journal (DMJ) - Open Access
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Indexed in SCIE (Science Citation Index Expanded)
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Table of Contents Alert
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| Volume 43(6); December 2019 |
| Featured Articles |
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| Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction? Diabetes Metab J. 2019 Dec;43(6):785-793. |
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Biochemical predictors of glucose metabolism and fasting indices of glucose homeostasis were assessed to predict gestational diabetes (GDM) and/or gestational diabetes with a need of pharmacotherapy (GDM-PT) later in pregnancy.
Fasting plasma glucose (FPG) (ROC-AUC 68.1%), fasting insulin (FI) (ROC-AUC 67.2%), and fasting C-peptide (FCP) (ROC-AUC 70.6%) showed moderate to high accuracy in predicting GDM and GDM-PT. HbA1c was less accurate (ROC-AUC 65.3%), probably because HbA1c is a weak surrogate marker of insulin secretion and resistance. Additionally, quantitative insulin sensitivity check index, QUICKIc, was identified as the best predictor factor for GDM (ROC-AUC 83.7%) in the GDM-PT collective.
Furthermore, FPG, QUICKIc at baseline and OGTT value at fasting were highly correlated with each other (r=0.48), but not with postprandial values (r=0.15). |
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| Relation between Baseline Height and New Diabetes Development: A Nationwide Population-Based Study. Diabetes Metab J. 2019 Dec;43(6):794-803. |
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| Short stature and leg length are associated with risk of diabetes and obesity. However, this association remains controversial and it is unclear whether this association is observed in Asians. Investigators studied new development of diabetes among 21,122,422 non-diabetic Koreans (mean age 43 years) enrolled in KNHS during median 5.6 year follow-up. The hazard ratio for diabetes development gradually increased from the 5th (reference) to 1st quintile group of baseline height after adjustment for confounding factors with statistical significance. In conclusion, height was inversely associated with diabetes risk in Korean adults. This association did not differ by sex, and was significant in lean individuals and those with normal FBG levels. |
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| Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome. Diabetes Metab J. 2019 Dec;43(6):830-839. |
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| The NOD-like receptor protein 3 (NLRP3) inflammasome is known to contribute to the progression of chronic kidney. The dipeptidyl peptidase-4 (DPP-4) inhibitors have shown protective effects on diabetic kidney disease, but the effect of gemigliptin on NLRP3 inflammasome activation in a model of renal fibrosis has not been fully investigated. We demonstrated that gemigliptin abrogated unilateral ureteral obstruction (UUO)-induced ECM accumulation. Furthermore, gemigliptin inhibited NLRP3 inflammasome activation and subsequent proinflammatory cytokine production in UUO kidney. The renoprotective effect of gemigliptin appears to be a consequence of down-regulated fibrotic gene expression via the suppression of TGF-β/NF-κB-induced NLRP3 inflammasome activation. |
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| Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action. Diabetes Metab J. 2019 Dec;43(6):854-866. |
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| Based on the previous findings that metformin plays a dual role in beta-cell dysfunction, we investigated the effect of low and high concentrations of metformin (0.05 and 0.5 mM) on beta-cell function under lipotoxic stress. Our findings reveal that metformin ameliorated palmitate-induced beta-cell dysfunction through a different mechanism depending on its concentration. High concentration of metformin activates AMPK, whereas low concentration of metformin, which is close to the concentration observed in the plasma of patients treated with usual clinical dose, suppresses ER stress and ROS levels elevated by lipotoxicity in an AMPK-independent manner. |
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| The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults. Diabetes Metab J. 2019 Dec;43(6):867-878. |
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This study aimed to investigate the relationship between different obesity phenotypes and thyroid function in Korean euthyroid adults. A total of 13,873 adults from the sixth Korea National Health and Nutrition Examination survey (KNHANES) were included. Subjects were divided into four obesity phenotype groups based on body mass index and metabolic status.
The present study demonstrates that serum free thyroxine (fT4) within the reference range was positively associated with metabolically healthy non-obese (MHNO) phenotype, although this association did not remain significant after adjustment for confounding factors. And thyrotropin (TSH) was negatively associated with MHNO phenotype. Higher normal serum fT4, but not TSH, was significantly associated with decreased prevalence of metabolic syndrome. |
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| Reviews |
| Complications |
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733
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Diabetes and Cancer: Cancer Should Be Screened in Routine Diabetes Assessment 
Suh S, Kim KW.
Diabetes Metab J. 2019 Dec;43(6):733-743. |
| Obesity and Metabolic Syndrome |
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744
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Adult Stem Cells: Beyond Regenerative Tool, More as a Bio-Marker in Obesity and Diabetes
Sen S.
Diabetes Metab J. 2019 Dec;43(6):744-751. |
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752
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Two Faces of White Adipose Tissue with Heterogeneous Adipogenic Progenitors
Hwang I, Kim JB.
Diabetes Metab J. 2019 Dec;43(6):752-762. |
| Editorial |
| Clinical Care/Education |
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763
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New Diagnostic Criteria for Gestational Diabetes Mellitus and Pregnancy Outcomes in Korea
Hur KY.
Diabetes Metab J. 2019 Dec;43(6):763-765. |
| Original Articles |
| Clinical Care/Education |
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766
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Pregnancy Outcomes of Women Additionally Diagnosed as Gestational Diabetes by the International Association of the Diabetes and Pregnancy Study Groups Criteria
Kim MH, Kwak SH, Kim SH, Hong JS, Chung HR, Choi SH, Kim MY, Jang HC.
Diabetes Metab J. 2019 Dec;43(6):766-775. |
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776
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Impact of Continuous Care on Health Outcomes and Cost for Type 2 Diabetes Mellitus: Analysis Using National Health Insurance Cohort Database
Nam JH, Lee C, Kim N, Park KY, Ha J, Yun J, Shin DW, Shin E.
Diabetes Metab J. 2019 Dec;43(6):776-784. |
| Clinical Diabetes & Therapeutics |
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785
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Early Assessment of the Risk for Gestational Diabetes Mellitus: Can Fasting Parameters of Glucose Metabolism Contribute to Risk Prediction?
Falcone V, Kotzaeridi G, Breil MH, Rosicky I, Stopp T, Yerlikaya-Schatten G, Feichtinger M, Eppel W, Husslein P, Tura A, Göbl CS.
Diabetes Metab J. 2019 Dec;43(6):785-793. |
| Epidemiology |
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794
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Relation between Baseline Height and New Diabetes Development: A Nationwide Population-Based Study
Rhee EJ, Cho JH, Kwon H, Park SE, Jung JH, Han KD, Park YG, Kim YH, Lee WY.
Diabetes Metab J. 2019 Dec;43(6):794-803. |
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804
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Diabetes and the Risk of Infection: A National Cohort Study
Kim EJ, Ha KH, Kim DJ, Choi YH.
Diabetes Metab J. 2019 Dec;43(6):804-814. |
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815
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Impact of Cytomegalovirus Disease on New-Onset Type 2 Diabetes Mellitus: Population-Based Matched Case-Control Cohort Study
Yoo SG, Han KD, Lee KH, La Y, Kwon DE, Han SH.
Diabetes Metab J. 2019 Dec;43(6):815-829. |
| Complications |
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830
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Gemigliptin Attenuates Renal Fibrosis Through Down-Regulation of the NLRP3 Inflammasome
Seo JB, Choi YK, Woo HI, Jung YA, Lee S, Lee S, Park M, Lee IK, Jung GS, Park KG.
Diabetes Metab J. 2019 Dec;43(6):830-839. |
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840
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Presence of Carotid Plaque Is Associated with Rapid Renal Function Decline in Patients with Type 2 Diabetes Mellitus and Normal Renal Function
Seo DH, Kim SH, Song JH, Hong S, Suh YJ, Ahn SH, Woo JT, Baik SH, Park Y, Lee KW, Kim YS, Nam M, on Behalf of the KNDP Study Group.
Diabetes Metab J. 2019 Dec;43(6):840-853. |
| Pathophysiology |
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854
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Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
Kim HI, Lee JS, Kwak BK, Hwang WM, Kim MJ, Kim YB, Chung SS, Park KS.
Diabetes Metab J. 2019 Dec;43(6):854-866. |
| Obesity and Metabolic Syndrome |
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867
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The Relationship between Thyroid Function and Different Obesity Phenotypes in Korean Euthyroid Adults
Kim JM, Kim BH, Lee H, Kim EH, Kim M, Kim JH, Jeon YK, Kim SS, Kim IJ, Kim YK.
Diabetes Metab J. 2019 Dec;43(6):867-878. |
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879
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Premeal Consumption of a Protein-Enriched, Dietary Fiber-Fortified Bar Decreases Total Energy Intake in Healthy Individuals
Ahn CH, Bae JH, Cho YM.
Diabetes Metab J. 2019 Dec;43(6):879-892. |
| Short Communications |
| Clinical Diabetes & Therapeutics |
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893
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Three Months Monitored Metabolic Fitness Modulates Cardiovascular Risk Factors in Diabetic Patients
Cirilli I, Silvestri S, Marcheggiani F, Olivieri F, Galeazzi R, Antonicelli R, Recchioni R, Marcheselli F, Bacchetti T, Tiano L, Orlando P.
Diabetes Metab J. 2019 Dec;43(6):893-897. |
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898
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A Lower Baseline Urinary Glucose Excretion Predicts a Better Response to the Sodium Glucose Cotransporter 2 Inhibitor
Hwang YC, Kim JH, Lee BW, Lee WJ.
Diabetes Metab J. 2019 Dec;43(6):898-905. |
| Letters |
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906
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Letter: Effects of Dapagliflozin on Endothelial Function, Renal Injury Markers, and Glycemic Control in Drug-Naïve Patients with Type 2 Diabetes Mellitus (Diabetes Metab J 2019:43:711–7)
Patoulias D, Doumas M.
Diabetes Metab J. 2019 Dec;43(6):906-908. |
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909
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Letter: Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J 2019;43:582–9)
Sohn TS.
Diabetes Metab J. 2019 Dec;43(6):909-910. |
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911
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Letter: Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study (Diabetes Metab J 2019;43:640–8)
Moon JS.
Diabetes Metab J. 2019 Dec;43(6):911-912. |
| Responses |
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913
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Response: Effects of Dapagliflozin on Endothelial Function, Renal Injury Markers, and Glycemic Control in Drug-Naïve Patients with Type 2 Diabetes Mellitus (Diabetes Metab J 2019:43:711–7)
Kong SH, Koo BK, Moon MK.
Diabetes Metab J. 2019 Dec;43(6):913-914. |
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915
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Response: Comparison of the Efficacy of Rosuvastatin Monotherapy 20 mg with Rosuvastatin 5 mg and Ezetimibe 10 mg Combination Therapy on Lipid Parameters in Patients with Type 2 Diabetes Mellitus (Diabetes Metab J 2019;43:582–9)
Hwang YC.
Diabetes Metab J. 2019 Dec;43(6):915-916. |
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917
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Response: Dipeptidyl Peptidase-4 Inhibitors versus Other Antidiabetic Drugs Added to Metformin Monotherapy in Diabetic Retinopathy Progression: A Real World-Based Cohort Study (Diabetes Metab J 2019;43:640–8)
Chung YR, Ha KH, Lee K, Kim DJ.
Diabetes Metab J. 2019 Dec;43(6):917-918. |
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Open Access
DMJ is an open access journal distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. It is indexed in KoreaMed, KoMCI, KoreaMed Synapse, PubMed, PubMed Central, SCOPUS, EMBASE, Ebsco, DOI/Crossref, Google Scholar, and Science Citation Index Expanded (SCIE).
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Manuscript Submission
Manuscripts should be submitted via an online manuscript-submission system of the Korean Diabetes Association (https://e-dmj.org, or http://submit.e-dmj.org).
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