Where Innovative Ideas Reunite

Lectures. Networking. Workshops.

In Session I, titled "Neurohormonal Control of Metabolism," attendees will delve into the complex interplay between the central nervous system (CNS) and metabolic processes. They will explore how amino acid levels can signal the CNS to regulate metabolism and how Nos1 neurons in the hypothalamus contribute to the use of fats in the body. The role of a specific mitochondrial peptide in energy balance will be discussed, along with how food odors can influence lipid utilization, potentially offering insights into preventing diabetes and depression. The session will also cover how p21-activated kinase 4 modulates fat breakdown through specific molecular interactions.

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Session II, "Adipose Biology, Multi-omics, and MASH," will focus on fat tissue dynamics, molecular pathways in lipid metabolism, and the development of liver diseases linked to fat and sugar imbalances. Discussions will include the cutting-edge single-cell analysis of human fat tissue and how cellular aging contributes to metabolic diseases such as steatohepatitis, providing a multi-omic perspective on adipose tissue regulation.

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In Session III, "Metabolite Signaling and Translational Potential in Diabetes," participants will learn about the role of lactate in muscle and intestinal functions, the impact of muscle mass on diabetes management, and the significance of protein metabolism in maintaining health. The session will also address how nutrient stress can induce autophagy, a cellular survival mechanism, with potential applications in diabetes treatment.

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Session IV, "New Targets and Therapeutics in Metabolic Diseases," will introduce novel therapeutic agents and targets in the treatment of metabolic disorders. Imeglimin's effects on various organs and metabolic pathways will be highlighted, as will the identification of CDCP1 as a potential biomarker for metabolic dysfunction. Additionally, the preservation of mitochondrial function as a therapeutic strategy in heart disease and the role of creatine in liver health will be discussed, offering attendees insights into cutting-edge research and emerging treatments for metabolic diseases.